PHARMACOLOGICAL SCREENING FOR ANTI-ARTHRITIC ACTIVITY OF MORINGA OLEIFERA
Abstract
Objective: The present study was performed to investigate the anti-arthritic activity of ethanolic and aqueous leaf extracts of Moringa oleifera (MO)against formaldehyde-induced arthritis in laboratory rats.
Methods: Arthritis was induced in albino Wistar rats by administration of 0.1 ml formaldehyde (2% v/v, sc) into subplantar region of the right hind
paw. Diclofenac sodium (10 mg/kg, i.p.) was used as the standard drug. The ethanolic leaf extracts of MO at doses of 250 and 500 mg/kg and aqueous
leaf extract at 500 mg/kg body weight p.o were administered for 10 days. At the end of the study period, changes in paw edema volume, paw thickness,
arthritis score, and C-reactive protein (CRP) levels were recorded along with histopathology of knee joints in all groups were studied.
Results: There was a significant reduction recorded in paw edema volume, paw thickness, arthritis score, and CRP levels on treatment with diclofenac
sodium, ethanolic and aqueous extracts of MO. When compared between the two extracts, aqueous extract in the dose of 500 mg/kg body weight was
found to be more potent.
Conclusion: The results demonstrated significant anti-arthritic activity of ethanolic and aqueous leaf extracts of MO at a dose of 500 mg/kg body
weight.
Keywords: Moringa oleifera, Formaldehyde, Arthritis, C-reactive protein.
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