INVOLVEMENT OF OXIDATIVE STRESS IN ISCHEMIC HEART DISEASE (IHD) IN PATIENTS ADMITTED IN A TERTIARY CARE HOSPITAL, WEST BENGAL, INDIA

Authors

  • Santanu Dutta
  • Debasri Mukherjee
  • Elina Mitra
  • Arnab K. Ghosh
  • Mousumi Dutta
  • Anjali Basu
  • Arup Das Biswas
  • Arun Bandyopadhyay
  • Debasish Bandyopadhyay

Keywords:

Ischemic Heart Disease, Oxidative stress, Hypertrophic cardiomyopathy, IschemiaReperfusion ratio (IR)

Abstract

Objectives: The present study is aimed at investigating the involvement of oxidative stress in ischemic heart disease (IHD) of patients in tertiary care hospital in Kolkata.

Methods: Serum parameters of myocardial injury, oxidative stress biomarkers and antioxidant enzymes were measured. These data were supported by the data of electrocardiography and echocardiography.

Results: The current studies indicate involvement of oxidative stress in Indian IHD patients, and assessing these biomarkers may be useful in diagnosis of patients with ischemic hypertrophic cardiomyopathy.

Conclusion: Cardiovascular diseases are becoming one of the leading health problems in India. The majority of cardiovascular diseases and related complications occur due to imbalance of oxidants and pro-oxidants in an individual. Thus, oxidative stress is one of the main factors in ischemic heart disease (IHD).

 

Downloads

Download data is not yet available.

References

Bandyopadhyay D, Chattopadhyay A, Ghosh G, Datta AG. Oxidative Stress-Induced Ischemic Heart Disease: Protection by Antioxidants, Curr Med Chem 2004; 11:369-387.

Maron MS, Olivotto I, Betocchi S. Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. N Engl J Med 2003;348:295–303.

Spirito P, Maron BJ. Relation between extent of left ventricular hypertrophy and diastolic filling abnormalities in hypertrophic cardiomyopathy. J Am Coll Cardiol 1990;15:808 –813.

Scolletta S, Carlucci F, Biagioli B, Marchetti L, Maccherini M, Carlucci G, Rosi F, Salvi M, Tabucchi A. NT-probnp changes, oxidative stress, and energy status of hypertrophic myocardium following ischemia/reperfusion injury. Biomed Pharmacother 2007;61:160-166.

Bandyopadhyay D, Bandyopadhyay A, Das PK, Reiter RJ. Melatonin protect against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage. J Pineal Res 2002;33:1-7.

Mukherjee D, Roy SG, Bandyopadhyay A, Chatyopadhyay A, Basu A, Mitra E, Ghosh AK, Reiter R, Bandyopadhyay D. Melatonin protects against isoproterenol-induced myocardial injury in the rat: antioxidative mechanisms. J Pineal Res 48:251–262, 2010.

Mukherjee D, Ghosh AK, Bandyopadhyay A, Basu A, Datta S. Pattari SK, Reiter RJ, Bandyopadhyay D. Melatonin protects against isoproterenol-induced alterations in cardiac mitochondrial energy-metabolizing enzymes, apoptotic proteins, and assists in complete recovery from myocardial injury in rats. J Pineal Res 53: 166-179, 2012.

Bandyopadhyay D, Biswas K, Bandyopadhyay U, Reiter RJ, Banerjee RK. Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical. J Pineal Res 2000;29:143-151.

Buege JA, Aust SG. Microsomal Lipid Peroxidation. Meth Enzymol 1978; 52:302-310.

Bandyopadhyay D, Ghosh G, Bandyopadhyay A, Reiter RJ. Melatonin protects against piroxicam-induced gastric ulceration. J Pineal Res 2004;36:195-203.

Sedlak J, Lindsay RH. Estimation of total, protein-bound, nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem 1968;25:192-205.

Martin J P, Daily M, Sugarman E. Negative and Positive assays of superoxide dismutase based on hematoxyline autooxidation. Arch Biochem Biophysi 1987; 255: 329-326.

Beers R F JR., Sizer I W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem1952; 195: 133-140. .

Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein Measurement with the Folin Reagent. J Biol Chem 1951;193: 265-275.

Johnson JN, Grifoni C, Bos JM, Saber-Ayad M, Ommen SR, Nistri S, Cecchi F, Olivotto I, Ackerman MJ. Prevalence and clinical correlates of QT prolongation in patients with hypertrophic cardiomyopathy. Eur Heart J 2011;32(9):1114-1120.

Cecchi F, Olivotto I, Montereggi A, Santoro G, Dolara A, Maron BJ. Hypertrophic cardiomyopathy in Tuscany: clinical course and outcome in an unselected regional population. J Am Coll Cardiol 1995;26: 1529–1536.

Wigle ED, Rakowski H, Kimball BP, Williams WG. Hypertrophic cardiomyopathy. Clinical spectrum and treatment. Circulation 1995; 92:1680 –1692.

Ghosh D, Firdaus SB, Mitra E, Dey M, Bandyopadhyay D. Protective effect of aqueous leaf extract of Murraya koenigi against lead induced oxidative stress in rat liver, heart and kidney: a dose response study. Asian J Pharm Clin Res 5 (4):2012

Elliott PM, Kaski JC, Prasad K, et al. Chest pain during daily life in patients with hypertrophic cardiomyopathy: an ambulatory electrocardiographic study. Eur Heart J 1996;17:1056–1064.

Chattopadhyay A, Das Choudhury T, Bandyopadhyay D, Datta A G: Protective effect of erythropoietin on the oxidative damage of erythrocyte membrane by hydroxyl radical. Biochem Pharmacol 2000;59:419-425.

Maron MS, Olivotto I, Maron BJ, Prasad SK, Cecchi F, Udelson JE, Camici PG. The case for myocardial ischemia in hypertrophic cardiomyopathy. J Am Coll Cardiol 2009;54(9):866-875.

Maron BJ. Hypertrophic cardiomyopathy: a systematic review. JAMA 2002; 287:1308 –1320.

Dhawan J, Bray CL, Angiographic comparison of coronary artery disease between Asians and Caucasians. Postgrad Med J 1994;70(827):625-630.

Tomas M, Latorre G, Senti M, Marrugat J. The antioxidants function of high density lipoproteins: a new paradigm in atherosclerosis. Rev Esp Cardiol 2004;57: 557- 569.

Kharb S, Singh GP. Effect of smoking on lipid profile, lipid peroxidation and antioxidant status in normal subjects and in patients during and after acute myocardial infarction. Clin Chim Acta 2000;302: 213-219.

Varbo A, Benn M, Tybjærg-Hansen A, Jørgensen AB, Frikke-Schmidt R, Nordestgaard BG. Remnant cholesterol as a causal risk factor for ischemic heart disease. J Am Coll Cardiol 2013; 61(4):427-436.

Mitra E, Ghosh AK, Ghosh D, Mukherjee D, Chattopadhyay A, Dutta S, Pattari SK, Bandyopadhyay D. Protective effect of aqueous Curry leaf (Murraya koenigii) extract against cadmium-induced oxidative stress in rat heart. Food Chem Toxicol 2012; 50(5):1340-1353.

Dutta M, Ghosh AK, Basu A, Bandyopadhyay D, Chattopadhyay A. Protective effect of aqueous bark extract of Terminalia arjuna against copper-ascorbate induced oxidative stress in vitro in goat heart mitochondria. Int J Pharm Pharm Sci 2013; 5 (2): 439-447.

Ghosh AK, Mitra E, Dutta M, Mukherjee D, Basu A, Firdaus SB, Bandyopadhyay D, Chattopadhyay A. Protective effect of aqueous bark extract of Terminalia arjuna on cu2+-ascorbate induced oxidative stress in vitro: involvement of antioxidant mechanism(s). Asian J Pharm Clin Res 6 (1): 196-200, 2013.

Mitra E, Ghosh AK, Ghosh D, Firdaus SB, Mukherjee D, Chattopadhyay A, Pattari SK, Dutta S, Bandyopadhyay D. Ameliorative effect of aqueous curry leaf (Murraya koenigii) extract against cadmium-induced oxidative stress in rat liver: involvement of antioxidant mechanisms. Int J Pharm Pharm Sci 5 (2): 570-583, 2013.

Published

01-07-2013

How to Cite

Dutta, S., D. Mukherjee, E. Mitra, A. K. Ghosh, M. Dutta, A. Basu, A. D. Biswas, A. Bandyopadhyay, and D. Bandyopadhyay. “INVOLVEMENT OF OXIDATIVE STRESS IN ISCHEMIC HEART DISEASE (IHD) IN PATIENTS ADMITTED IN A TERTIARY CARE HOSPITAL, WEST BENGAL, INDIA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 6, no. 3, July 2013, pp. 161-6, https://journals.innovareacademics.in/index.php/ajpcr/article/view/150.

Issue

Section

Articles