WOUND HEALING ACTIVITY OF TOPICAL MENTHA PIPERITA AND CYMBOPOGAN CITRATUS ESSENTIAL OIL ON STREPTOZOTOCIN INDUCED RATS

Umasankar K, Balwin Nambikkairaj, Manley Backyavathy D

Abstract


A common complication of diabetes is impaired wound healing. Systemic Mentha piperita and Cymbopogan citratus essential  oil improves healing in diabetics, which is dose dependent, and may have side effects. There is a very less information regarding topical Mentha piperita and Cymbopogan citratus use. The objective of this study was to evaluate the effects of topical Mentha piperita and Cymbopogan citratus oil on wound healing.  Diabetes was induced in wistar rats by using streptozotocin. The control group comprised age-matched animals not submitted to streptozotocin injection. Diabetic state was confirmed by glycosuria and hyperglycemia. Under tribromoethanol anesthesia, Diabetic induced infected wound treatment with topical Mentha piperita ointment treatment and their another essential ointment in Cymbopogan citratus wound contraction studies a circular piece 08 mm2 in area 20th days compared wound healing study on  the  wound  contraction  studies a circular piece 08mm2 in area 18th days  highly effective in Mentha piperita ointment.  Then non diabetic wound healing control on the  wound  contraction  studies  a  circular piece 07 mm2 in area12th days, complete wound healing activity  and diabetic wound   control compared with diabetic  infected wound treatment Mentha piperita ointment  with  highly effective  wound healing activity histological, histometric and stereological methods were used for the analysis. Topical Mentha piperita   and Cymbopogan citratus accelerated wound closure in diabetic and non-diabetic rats and the results were found to be more active than antibiotic treated controls. Topical Mentha piperita   and Cymbopogan citratus could be helpful in diabetics, in order to improve the wound healing process avoiding possible adverse effects from systemic medication. All the values are statistically significant.

Keywords:

Topical Mentha piperita oil, Cymbopogan citratus oil, Wistar rats,                       Hematological  and  Histopathological factors, diabetes  wound healing.


Full Text:

180-183

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