WOUND HEALING ACTIVITY OF TOPICAL MENTHA PIPERITA AND CYMBOPOGAN CITRATUS ESSENTIAL OIL ON STREPTOZOTOCIN INDUCED RATS
A common complication of diabetes is impaired wound healing. Systemic Mentha piperita and Cymbopogan citratus essential oil improves healing in diabetics, which is dose dependent, and may have side effects. There is a very less information regarding topical Mentha piperita and Cymbopogan citratus use. The objective of this study was to evaluate the effects of topical Mentha piperita and Cymbopogan citratus oil on wound healing. Diabetes was induced in wistar rats by using streptozotocin. The control group comprised age-matched animals not submitted to streptozotocin injection. Diabetic state was confirmed by glycosuria and hyperglycemia. Under tribromoethanol anesthesia, Diabetic induced infected wound treatment with topical Mentha piperita ointment treatment and their another essential ointment in Cymbopogan citratus wound contraction studies a circular piece 08 mm2 in area 20th days compared wound healing study on the wound contraction studies a circular piece 08mm2 in area 18th days highly effective in Mentha piperita ointment. Then non diabetic wound healing control on the wound contraction studies a circular piece 07 mm2 in area12th days, complete wound healing activity and diabetic wound control compared with diabetic infected wound treatment Mentha piperita ointment with highly effective wound healing activity histological, histometric and stereological methods were used for the analysis. Topical Mentha piperita and Cymbopogan citratus accelerated wound closure in diabetic and non-diabetic rats and the results were found to be more active than antibiotic treated controls. Topical Mentha piperita and Cymbopogan citratus could be helpful in diabetics, in order to improve the wound healing process avoiding possible adverse effects from systemic medication. All the values are statistically significant.
Topical Mentha piperita oil, Cymbopogan citratus oil, Wistar rats, Hematological and Histopathological factors, diabetes wound healing.
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