PATTERN OF ADVERSE DRUG REACTIONS IN A TERTIARY CARE TEACHING HOSPITAL: A CROSS-SECTIONAL STUDY


Sangeetha Raja, Jamuna Rani R, Kala P

Abstract


ABSTRACT
Objective: The aim of this study was to carry out adverse drug reactions (ADRs) monitoring in various departments of a tertiary care teaching hospital.
Methods: A cross-sectional study was conducted on ADRs reported in the hospital from December 2012 to May 2013 after obtaining Institutional
Ethics Committee approval.
Results: A total of 40 ADRs were reported, 47.50% were males and 52.50% were females. The female adult population was 45%. The majority of ADRs
were due to antimicrobial agents especially beta-lactam antibiotics (42.5%) followed by NSAIDs (7.50%). A maximum number of patients (75%)
were reported with dermatological manifestations. The department of medicine reported the highest number of ADRs (37.5%). As per Naranjo’s
probability scale, 62.5% reports were assessed as probable. 62.5% reports were documented as mild according to Modified Hartwig’s criteria for
severity assessment.
Conclusion: This study was done to sensitize the practicing physicians on the importance of adverse drug monitoring and reporting.
Keywords: Pharmacovigilance, Adverse drug reactions, Tertiary care teaching hospital, Antimicrobial agents.


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References


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Table 1: Types of reactions for drugs in reported ADRs

Reactions

Drugs

Number of ADRs (%)

Urticaria

Ceftriaxone with sulbactam, Ceftriaxone, Ceftriaxone with tazobactam, Cefotaxime, Phenytoin, Ciprofloxacin, Cotrimoxazole, Metronidazole

(62.5)

Erythematous skin lesion

Diclofenac sodium, Cotrimoxazole, Paracetamol, Phenytoin, Carbamezapine, Clindamycin

(18.75)

Chest tightness and pain

Metronidazole, Iopamide

(6.25)

Throat irritation

Ciprofloxacin

(3)

Facial edema

Cefotaxime

(3)

Rigor

Vancomycin

(3)

Lip edema

Cotrimoxazole

(3)

ADRs: Adverse drug reactions

Table 2: List of organs system in ADRs

Organ system

Number of ADRs (%)

Skin

Gastrointestinal system

Cardiovascular system

Central nervous system

Respiratory

Genitourinary

Eyes, ears, nose and throat

ADRs: Adverse drug reactions

Asian J Pharm Clin Res, Vol 10, Issue 3, 2017, 170-173

Raja et al.

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About this article

Title

PATTERN OF ADVERSE DRUG REACTIONS IN A TERTIARY CARE TEACHING HOSPITAL: A CROSS-SECTIONAL STUDY

DOI

10.22159/ajpcr.2017.v10i3.15972

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 170-173

Print ISSN

0974–2441

Online ISSN

2455-3891

Statistics

56 Views | 0 Downloads

Authors & Affiliations

Sangeetha Raja
Department of Pharmacology, SRM Medical College Hospital & Research Centre, Potheri-603203, Kancheepuram District, Tamilnadu, India.
India

Jamuna Rani R
Department of Pharmacology, SRM Medical College Hospital & Research Centre, Potheri-603203, Kancheepuram District, Tamilnadu, India.
India

Kala P
Department of Pharmacology, SRM Medical College Hospital & Research Centre, Potheri-603203, Kancheepuram District, Tamilnadu, India.


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