IN VITRO ANTIOXIDANT ACTIVITY, IN VIVO ANTIPYRETIC AND ANTI-INFLAMMATORY ACTIVITIES OF PARONYCHIA CAPITATA L.
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i3.15981Abstract
ABSTRACT
Objective: The aim of this study is to evaluate the in vitro antioxidant activity of Paronychia capitata various extracts, acute toxicity, the in vivo
antipyretic and anti-inflammatory activities of the n-butanol extract.
Methods: The antioxidant properties were tested using 2,2-diphenyl 1-picrylhydrazyl radical scavenging and β-carotene linoleic acid system, the
total phenolic and flavonoid contents were determined. Furthermore, anti-inflammatory activity and antipyretic activity of the n-butanol extract
were assessed on male Wistar rats at the dose levels 250, 500 mg/kg body weight, using the egg albumin-induced edema, and brewer's yeast-induced
pyrexia method, respectively.
Results: The n-butanol extract of P. capitata had considerably the highest antiradical activity with inhibitory concentration 50 value of 8.667 μg/ml.
Conclusion: The experimental data demonstrated that n-butanol extract of P. capitata possess significantly remarkable anti-inflammatory and
antipyretic activities compared to the standard drugs.
Keywords: Caryophyllaceae, Flavonoid, Inflammation, Fever, Paronychia capitata.
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