MESENCHYMAL STEM CELLS: AN INNOVATIVE APPROACH IN PHARMACOKINETICS
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i3.16023Abstract
ABSTRACT
Multipotent mesenchymal stem cells (MSCs) are special kind of stem cells which originate from mesenchyme. These cells can be used as an imperative
tool to study reproductive toxicity, carcinogenicity, mutagenicity, genotoxicity, and pharmacokinetics. This novel system may reveal toxicantinduced
etiology, decipher detailed understanding on molecular mechanisms of toxicants induced pathways and also enumerate the safe dose of
an investigational product. Hence, this could ultimately replace, improve or overtake current predictive models in toxicology. The particular review
describes the utilization of MSCs in different field of toxicological and pharmacological research.
Keywords: Mesenchymal stem cells, Toxicant, Etiology, Pharmacokinetics.
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