FEBRILE INFECTION-RELATED EPILEPSY SYNDROME: A RARE CASE PRESENTATION
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i3.16045Abstract
ABSTRACT
Febrile infection-related epilepsy syndrome is characterized by super refractory status epilepticus that is resistant to conventional antiepileptic drugs.
This case report critically analyses the treatment options adopted in a hospital to manage this syndrome. Despite the aggressive efforts that were
taken, the patient succumbed to the complications of the illness and side effects of the treatment strategies adopted. This shows that the treatment
options currently available are in adequate, so an intensive research in the area of pathogenesis of status epilepticus is required to frame treatment
strategies that can bring out better outcomes.
Keywords: Antiepileptics, Febrile infection-related epilepsy syndrome, Status epilepticus.
Downloads
References
REFERENCES
Mikaeloff Y, Jambaqué I, Hertz-Pannier L, Zamfirescu A, Adamsbaum C, Plouin P, et al. Devastating epileptic encephalopathy in school-aged children (DESC): A pseudo encephalitis. Epilepsy Res 2006;69(1):67-79.
van Baalen A, Stephani U, Kluger G, Häusler M, Dulac O. FIRES: Febrile infection responsive epileptic (FIRE) encephalopathies of school age. Brain Dev 2009;31(1):91.
van Baalen A, Häusler M, Boor R, Rohr A, Sperner J, Kurlemann G, et al. Febrile infection-related epilepsy syndrome (FIRES): A nonencephalitic encephalopathy in childhood. Epilepsia 2010;51(7):1323-8.
Kramer U, Chi CS, Lin KL, Specchio N, Sahin M, Olson H, et al. Febrile infection-related epilepsy syndrome (FIRES): Pathogenesis, treatment, and outcome: A multicenter study on 77 children. Epilepsia 2011;52(11):1956-65.
Nabbout R, Vezzani A, Dulac O, Chiron C. Acute encephalopathy with inflammation-mediated status epilepticus. Lancet Neurol 2011;10(1):99-108.
Kramer U, Chi CS, Lin KL, Specchio N, Sahin M, Olson H, et al. Febrile infection-related epilepsy syndrome (FIRES): Does duration of anesthesia affect outcome? Epilepsia 2011;52 Suppl 8:28-30.
Jackson JH. Remarks on the diagnosis and treatment of diseases of the brain. Br Med J 1888;2(1437):59-63.
Towne AR, Garnett LK, Waterhouse EJ, Morton LD, DeLorenzo RJ. The use of topiramate in refractory status epilepticus. Neurology 2003;60(2):332-4.
Vezzani A, Balosso S, Aronica E, Ravizza T. Basic mechanisms of status epilepticus due to infection and inflammation. Epilepsia 2009;50 Suppl 12:56-7.
Vezzani A, Rüegg S. The pivotal role of immunity and inflammatory processes in epilepsy is increasingly recognized: Introduction. Epilepsia 2011;52 Suppl 3:1-4.
Maroso M, Balosso S, Ravizza T, Liu J, Aronica E, Iyer AM, et al. Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med 2010;16(4):413-9.
Fisher RS, Kaplan PW, Krumholz A, Lesser RP, Rosen SA, Wolff MR. Failure of high-dose intravenous magnesium sulfate to control myoclonic status epilepticus. Clin Neuropharmacol 1988;11(6):537-44.
Orlowski JP, Erenberg G, Lueders H, Cruse RP. Hypothermia and barbiturate coma for refractory status epilepticus. Crit Care Med 1984;12(4):367-72.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
