EVALUATION OF ANTIULCEROGENIC ACTIVITY OF METHANOL EXTRACTS OF BRASSICA OLERACEA VAR. CAPITATA RUBRA ON ALBINO RAT GASTRIC ULCERATION


K.sudha Rameshwari, Ayshwarya M

Abstract


ABSTRACT
Objective: To investigate the antiulcerogenic activity of methanolic extract of Brassica var. capitata rubra in albino rats.
Methods: To evaluate the antiulcer activity by pyloric ligation models experimentally induced gastric ulcer by ranitidine (10 mg/kg) subcutaneously.
The parameters taken to assess antiulcer activity were free acidity, total acidity, volume of gastric juice, PH, ulcer score, and ulcer index.
Results: The methanolic extract of Brassica oleracea var. capitata rubra in the dose of 0.50 mg/kg produced significant antiulcer activity. The control
animals had ulcers and hemorrhagic streaks, whereas in animals administered with extracts of B. oleracea there was a significant reduction in ulcer
index (p˂0.05).
Conclusion: This study concluded that methanol extract of B. oleracea var. capitata has healing property of gastric ulcers in albino rats.
Keywords: Brassica, Methanol extract, Antiulcer activity, Pyloric ligation model.


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About this article

Title

EVALUATION OF ANTIULCEROGENIC ACTIVITY OF METHANOL EXTRACTS OF BRASSICA OLERACEA VAR. CAPITATA RUBRA ON ALBINO RAT GASTRIC ULCERATION

DOI

10.22159/ajpcr.2017.v10i3.16217

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 314-317

Print ISSN

0974–2441

Online ISSN

2455-3891

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20 Views | 46 Downloads

Authors & Affiliations

K.sudha Rameshwari
V.V.VANNIAPERUMAL COLLEGE FOR WOMEN, VIRUDHUNAGAR, TAMILNADU
India

Ayshwarya M
V.V.VANNIAPERUMAL COLLEGE FOR WOMEN, VIRUDHUNAGAR, TAMILNADU
India


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