EVALUATION OF ANTIULCEROGENIC ACTIVITY OF METHANOL EXTRACTS OF BRASSICA OLERACEA VAR. CAPITATA RUBRA ON ALBINO RAT GASTRIC ULCERATION

Authors

  • SUDHARAMESHWARI K V.V.VANNIAPERUMAL COLLEGE FOR WOMEN, VIRUDHUNAGAR, TAMILNADU
  • Ayshwarya M V.V.VANNIAPERUMAL COLLEGE FOR WOMEN, VIRUDHUNAGAR, TAMILNADU

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i3.16217

Abstract

ABSTRACT
Objective: To investigate the antiulcerogenic activity of methanolic extract of Brassica var. capitata rubra in albino rats.
Methods: To evaluate the antiulcer activity by pyloric ligation models experimentally induced gastric ulcer by ranitidine (10 mg/kg) subcutaneously.
The parameters taken to assess antiulcer activity were free acidity, total acidity, volume of gastric juice, PH, ulcer score, and ulcer index.
Results: The methanolic extract of Brassica oleracea var. capitata rubra in the dose of 0.50 mg/kg produced significant antiulcer activity. The control
animals had ulcers and hemorrhagic streaks, whereas in animals administered with extracts of B. oleracea there was a significant reduction in ulcer
index (p˂0.05).
Conclusion: This study concluded that methanol extract of B. oleracea var. capitata has healing property of gastric ulcers in albino rats.
Keywords: Brassica, Methanol extract, Antiulcer activity, Pyloric ligation model.

Downloads

Download data is not yet available.

Author Biographies

SUDHARAMESHWARI K, V.V.VANNIAPERUMAL COLLEGE FOR WOMEN, VIRUDHUNAGAR, TAMILNADU

DEPARTMENT OF PG BIOCHEMISTRY,

SENIOR [SELF]

Ayshwarya M, V.V.VANNIAPERUMAL COLLEGE FOR WOMEN, VIRUDHUNAGAR, TAMILNADU

II PG Biochemistry students, University rank holder,Class first

References

REFERENCES

Akhtar MS, Khtar AH, Khan MA. Antiulcerogenic effects of Ocimum basilicum of extracts, volatile oils and flavonoid glycosides in albino rats. Int J Pharmacogn 1992;30:97-8.

Hassimotto NM, Genovese MI, Lajolo FM. Antioxidant activity of dietary fruits, vegetables, and commercial frozen fruit pulps. J Agric Food Chem 2005;53:2928-35.

Arapitsas P, Turner C. Pressurized solvent extraction and monolithic column-HPLC/DAD analysis of anthocyanins in red cabbage. Talanta 2008;74:1218-23.

Barbara P, Grażyna HC, Emilia M, Sylwester C. Stability and antioxidative properties of acylated anthocyanins in three cultivars of red cabbage (Brassica oleracea L. var. capitata L. f. rubra). J Sci Food Agric 2009;89:1154-8.

Kyung KH, Fleming HP. S-methyl-L-cysteine sulfoxide as the precursor of methyl methanethiolsulfinate, the principal antibacterial compound in cabbage. J Food Sci 1994;59:350-5.

Hu SH, Wang JC, Kung HF, Wang JT, Lee WL, Yang YH. Antimicrobial effect of extracts of Cruciferous vegetables. Kaohsiung J Med Sci 2004;20:591-9.

Ayaz FA, Hayırlıoglu. Phenolic acid contents of kale (Brassica oleraceae L. var. Acephala DC.) extracts and their antioxidant and antibacterial activities. Food Chem 2008;107:19-25.

Zhou K, Yu L. Total phenolic contents and antioxidant properties of commonly consumed vegetables grown in Colorado. LWT - Food Sci Technol 2006;39:1155-62.

Andarwulan N, Batari R, Sandrasari DA, Bolling B, Wijaya, H. Flavonoid content and antioxidant activity of vegetables from Indonesia. Food Chem 2010;121:1231-5.

Isabelle M, Lee BL, Lim MT, Koh WP, Huang D, Ong CN. Antioxidant activity and profiles of common vegetables in Singapore. Food Chem 2010;120:993-1003.

Samec D, Piljac-Zegarac J, Bogovi M. Antioxidant potency of white (Brassica oleracea L. var. capitata) and Chinese (Brassica rapa L. var. Pekinensis (Lour.)) cabbage: The influence of development stage, cultivar choice and seed selection. Sci Hortic 2011;128:78-83.

Ayshwarya M, Sudha Rameshwari. K. Qualitative and quantitative analysis of phytochemicals in Brassica oleracea var capitata rubra. Int J Multidisciplinary Res 2015;4 (6):120-36.

Ayshwarya M, Sudha Rameshwari K. Antimicrobial activity of the plant extracts of Brassica oleracea var. Capitata rubra. J Int Acad Res Multidiscip 2015a;3(10):149-56.

Ayshwarya M, Sudha Rameshwari K. Assessment of antioxidant activity in Brassica oleracea var. capitata rubra. J Med Sci Clin Res 2015b;3(12):8536-41.

Rameshwari KS, Ayshwarya M. Anti-inflammatory and antipyretic activity of methanol extracts Brassica oleracea var capitata rubra in Wister rats. Int J Curr Res 2016;8(03):27299-302.

Kulkarni SS. Practical Pharmacology and Clinical Pharmacy. Delhi: Vallash Publication; 2008.

Gordan MH. The mechanism of the anti-oxidant action in vitro. In: Hudson BJ, editor. Food Antioxidants. London: Elsevier; 1990. p. 1-18.

Szabo S, Szienji S. ‘Cytoprotection’ in gastrointestinal pharmacology. Trends Pharma Sci 1987;8:149-154.

Aly A, Scand. J. Prostaglandins in clinical treatment of gastro duodenal mucosal lesions: A review. Gastroenterol 1987;137:43-9.

de Carvalho CA, Fernandes KM, Matta SL, Silva MB, Oliveira LL, Fonseca CC. Evaluation of antiulcerogenic activity of aqueous extract of Brassica oleracea var. Capitata (CABBAGE) on wistar rat gastric ulceration. Arq Gastroenterol 2011;48(4): 276-82.

Vinothapooshan G, Sundar K. Anti-ulcer activity of Mimosa pudica leaves against gastric ulcer in rats. Res J Pharm Biol Chem Sci 2010;1(4):606-14.

Cheney G. Vitamin U therapy of peptic ulcer. Calif Med 1952;77 (4):248-52.

Gonzalez FG, Di Stasi LC. Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice. Phytomedicine 2002;9 (2):125-34.

Tiwari DK, Tripathi RK, Jena J. Evaluation of antiulcer and antianxiety activity of phanamixispolystachya stems bark extract on rats. Int J Pharm Pharm Sci 2013;5:148-51.

Harvey AL, Edrada-Ebel R, Quinn RJ. The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov 2015;14:111-29.

Sayed DA, Fahmy SR, Soliman AM, Hussein NS. Antiulcerogenic efficacy of an ethanolic extract of Vitis vinifera leaves in rats. Int J Pharm Pharm Sci 2016;8(9):163-72.

Fahmy SR, Amer MA, Al-killidar MH. Ameliorative effect of the sea cucumber Holothuriaarenicola extracts against gastric ulcer in rats. J Basic Appl Zool 2015;72:16-25.

Nagar H, Tiwari P, Jain DK, Chandel HS. Evaluation of the antiulcer activity of stem bark extract of Aphanmixis polystachya in experimental rats. Indian J Pharm Educ Res 2012;46:222-7.

Bighetti AE, Antonio MA, Kohn LK, Rehder VL, Foglio MA,Possenti A, et al. The Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikanialaevigata Schultz bip. Phytomedicine 2005;12:72-7.

John-Africa BL, Idris-Usman MS, Adzu B, Gamaniel KS. Protective effects of the aqueous extract of Nymphaea lotus L. (Nymphaeaceae) against ethanol-induced gastric ulcers. Int J Biol Chem Sci 2012;6:1917-25.

Rai U, Pattnaik AK, Singh S. Antiulcer activity of the most active sub-fraction of methanolic leaf extract of Buchanania lanzan spreng. Int J Pharm Pharm Sci 2016;8(9):93-101.

Published

01-03-2017

How to Cite

K, S. ., and A. M. “EVALUATION OF ANTIULCEROGENIC ACTIVITY OF METHANOL EXTRACTS OF BRASSICA OLERACEA VAR. CAPITATA RUBRA ON ALBINO RAT GASTRIC ULCERATION”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 3, Mar. 2017, pp. 314-7, doi:10.22159/ajpcr.2017.v10i3.16217.

Issue

Section

Original Article(s)