USAGE OF SUGAR ESTER IN THE PREPARATION OF AVOCADO OIL NANOEMULSION
Abstract
ABSTRACT
Objectives: Due to the high dynamics of pharmaceutical products markets, developments of new products using latest innovative technology are
becoming a norm of many pharmaceutical companies. Nanoscale materials such as nanoemulsion (NE) offer advantages such as the controllable
droplet size, long-term stability, and power solubilization ability. It is beneficial in various delivery systems either for transdermal, ocular, nasal,
vaginal, and parenteral drug delivery. The objective of the study was to prepare avocado oil NE using different surfactants to find the most suitable
nanosized droplets, as avocado oil offers a variety of purported nutritional and medicinal benefits.
Methods: Sucrose esters, glycerol, and avocado oil with different ratio were used to produce pre-NE by phase inversion technique then pre-NE
were self-emulsified with water to produce NE. The influence of the sucrose esters surfactants on the NE formulations were determined using three
different types of sucrose esters surfactant (laureate, oleate, and palmitate). Stability study was conducted for NE at different temperatures (4°C, 25°C,
and 40°C) for 6 months.
Results: The NE contained sucrose laureate produced best nanosized formulations compared to other oleate and palmitate, with optimum droplet
size 106 ± 1.70 nm, size distribution 0.156 ± 0.01, and zeta potential −30.4 ± 0.70. The NE formulations were very stable at 4°C compared to 25°C and
40°C while at 25°C NE showed moderate stability, but it was unstable at 40°C.
Conclusion: Sucrose laureate was able to produce NE with phase inversion and self-emulsification techniques and the ideal storage condition for NE is 4°C.
Keywords: Avocado oil, Nanoemulsions, Self-nanoemulsification, Phase inversion technique, Sucrose ester, Stability.
Downloads
References
REFERENCES
Cortes-Munoz M, Chevalier-Lucia D, Dumay E. Characteristics of
submicron emulsions prepared by ultra-high pressure homogenisation:
Effect of chilled or frozen storage. Food Hydrocoll 2009;23(3):640-54.
Salvia-Trujillo L, Rojas-Grau MA, Soliva-Fortuny R, MartÃn-Belloso O.
Effect of processing parameters on physicochemical characteristics of
microfluidized lemongrass essential oil-alginate nanoemulsions. Food
Hydrocoll 2013;30(1):401-7.
Hino T, Kawashima Y, Shimabayashi S. Basic study for stabilization of
w/o/w emulsion and its application to transcatheter arterial embolization
therapy. Adv Drug Deliv Rev 2000;45:27-45.
Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma M.
Nano‑emulsions. Curr Opin Colloid Interface Sci 2005;10(3):102-10.
Ee SL, Duan X, Liew J, Nguyen QD. Droplet size and stability of
nano‑emulsions produced by the temperature phase inversion method.
Chem Engg J 2008;140(1):626-31.
Gutierrez J, González C, Maestro A, Sole I, Pey C, Nolla J.
Nano‑emulsions: New applications and optimization of their
preparation. Curr Opin Colloid Interface Sci 2008;13(4):245-51.
Leong TS, Wooster TJ, Kentish SE, Ashokkumar M. Minimising
oil droplet size using ultrasonic emulsification. Ultrason Sonochem
;16:721-7.
Rajpoot P, Pathak K, Bali V. Therapeutic applications of nanoemulsion
based drug delivery systems: A review of patents in last two decades.
Recent Pat Drug Deliv Formul 2011;5:163-72.
Mou D, Chen H, Du D, Mao C, Wan J, Xu H, et al. Hydrogel-thickened
nanoemulsion system for topical delivery of lipophilic drugs. Int J
Pharm 2008;353(1-2):270-6.
Wu H, Ramachandran C, Weiner ND, Roessler BJ. Topical transport of
hydrophilic compounds using water-in-oil nanoemulsions. Int J Pharm
;220(1-2):63-75.
Azeem A, Ahmad FJ, Khar RK, Talegaonkar S. Nanocarrier for the
transdermal delivery of an antiparkinsonian drug. AAPS PharmSciTech
;10:1093-103.
Haiyan Z, Bedgood Jr DR, Bishop AG, Prenzler PD, Robards K.
Endogenous biophenol, fatty acid and volatile profiles of selected oils.
Food Chem 2007;100(4):1544-51.
Ikhuoria E, Maliki M. Characterization of avocado pear
(Persea americana) and African pear (Dacryodes edulis) extracts. Afr J
Biotechnol 2007;6(7):950-2.
Pacetti D, Boselli E, Lucci P, Frega NG. Simultaneous analysis
of glycolipids and phospholids molecular species in avocado
(Persea americana Mill) fruit. J Chromatogr A 2007;1150(1-2):241-51.
Ojewole JA, Kamadyaapa DR, Gondwe MM, Moodley K,
Musabayane CT. Cardiovascular effects of Persea americana Mill
(Lauraceae) (avocado) aqueous leaf extract in experimental animals.
Cardiovasc J Afr 2007;18:69-76.
Logaraj T, Bhattacharya S, Udaya Sankar K, Venkateswaran G.
Rheological behaviour of emulsions of avocado and watermelon oils
during storage. Food Chem 2008;106(3):937-43.
Adeyemi OO, Okpo SO, Ogunti OO. Analgesic and anti-inflammatory
effects of the aqueous extract of leaves of Persea americana Mill
(lauraceae). Fitoterapia 2002;73(5):375-80.
RodrÃguez-Carpena JG, Morcuende D, Estévez M. Avocado, sunflower
and olive oils as replacers of pork back-fat in burger patties: Effect
on lipid composition, oxidative stability and quality traits. Meat Sci
;90:106-15.
Ding H, Chin YW, Kinghorn AD, D’Ambrosio SM. Chemopreventive
characteristics of avocado fruit. Semin Cancer Biol 2007;17:386-94.
Orhevba B, Jinadu A. Determination of physico-chemical properies and
nutritional contents of Avocado pear (Persea Amrticana M). Acad Res
Int 2011;1(3):372-80.
Szuts A, Szabo-Revesz P. Sucrose esters as natural surfactants in drug
delivery systems--a mini-review. Int J Pharm 2012;433(1-2):1-9.
Eid AM, El-Enshasy HA, Aziz R, Elmarzugi NA. The preparation and
Asian J Pharm Clin Res, Vol 8, Issue 4, 2015, 66-69
Eid et al.
evaluation of self-nanoemulsifying systems containing Swietenia oil
and an examination of its anti-inflammatory effects. Int J Nanomedicine
;9:4685-95.
Eid A, Elmarzugi N, El-Enshasy H, Arafat O. A novel Swietenia
macrophylla oil self-nanoemulsifying system: Development and
evaluation. Int J Pharm Pharm Sci 2013;5 Suppl 3:639-44.
Kim HJ, Phenrat T, Tilton RD, Lowry GV. Effect of kaolinite, silica
fines and pH on transport of polymer-modified zero valent iron
nano‑particles in heterogeneous porous media. J Colloid Interface Sci
;370(1):1-10.
Eid A, El-Enshasy H, Aziz R, Elmarzugi N. Preparation, characterization
and anti-inflammatory activity of swietenia macrophylla nanoemulgel.
J Nanomed Nanotechnol 2014;5(2):1-10.
Affandi MM, Julianto T, Majeed A. Development and stability
evaluation of astaxanthin nanoemulsion. Asian J Pharm Clin Res
;4(1):142-8.
Sevcikova P, Vltavska P, Kasparkova V, Krejci J. Formation,
characterization and stability of nanoemulsions prepared by phase
inversion. Mathematical and Computational Methods in Science and
Engineering, 2011. p. 132-7.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.