OPTIMIZATION AND SOLUBILIZATION STUDY OF NOVEL NANOEMULSION FORMULATION FOR 5-FLUOROURACIL BY APPLYING PSEUDOTERNARY PHASE DIAGRAM

Abstract

Objective: The aim of the present study was to formulate, optimize 5 fluorouracil nanoemulsions for targeting brain tumor.

Method: 5 Fluorouracil is an anticancer drug which has it effects on many types of tumor. The formulation was optimized for different components and the solubility study for the oil in surfactant & co-surfactant mix ratio was optimized using ternary phase diagram.

Result: The Smix ratio was optimized as 1:1 where the maximum concentration of the oil has solubilized and the nanoemulsion area was increased.

Conclusion: 5 Fluorouracil nanoemulsion for targeting brain tumor and the pseudo ternary phase diagram for the solubility studies and the components of different phases were optimized and achieved through this study.

Key Words: Nanoemulsion, 5-Fluorouracil, Pseudoternary phase diagram solubility, anti-cancer effect.