DOSE DEPENDENT EFFECT ON HYPOGLYCEMIC AND ANTIHYPERGLYCEMIC ACTIVITIES OF CHLOROFORM EXTRACT OF PHYSALIS MINIMA IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Authors

  • Swathi Putta AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam
  • Vijay Chedalawada Department of pharmacology, PRIST University, Tanjavur

Keywords:

Antidiabetic activity, Physalis minima, Oral glucose tolerance test, Streptozotocin, Triglycerides

Abstract

This study was undertaken to investigate the effect of chloroform extract of Physalis minima (CPM) whole plant on blood glucose levels and other biochemical parameters in streptozotocin (55 mg/kg. b. w., i. p) induced diabetic rats. The treatment was given at doses of (200, 300 and 400mg/kg. b. w., p. o), for 28 days. After the treatment with there is a significant reduction was observed in fasting blood glucose levels in treated diabetic rats. The CPM showed considerable lowering effect of total cholesterol, triglycerides, LDL & VLDL levels and considerably increase HDL cholesterol levels. There is a significant reduction of the SGOT, SGPT and ALP levels in diabetic rats treated with CPM, compared with disease control group. These results suggest that Physalis minima possesses antidiabetic activity in streptozotocin induced diabetic rats.

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Published

07-10-2014

How to Cite

Putta, S., and V. Chedalawada. “DOSE DEPENDENT EFFECT ON HYPOGLYCEMIC AND ANTIHYPERGLYCEMIC ACTIVITIES OF CHLOROFORM EXTRACT OF PHYSALIS MINIMA IN STREPTOZOTOCIN INDUCED DIABETIC RATS”. International Journal of Current Pharmaceutical Research, vol. 6, no. 4, Oct. 2014, pp. 61-65, https://journals.innovareacademics.in/index.php/ijcpr/article/view/3400.

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