FORMULATION AND EVALUATAION OF COLON TARGETED MATRIX TABLET OF NAPROXEN
Keywords:
Colon targeted drug delivery, Naproxen, Chronopharmaceutical drug delivery, Rheumatiod arthritis, Xanthan gum, ChitosanAbstract
Objectives: The objective of the present study is to formulate the Colon targeted delivery containing Naproxen for chronopharmaceutical drug delivery system (ChrDDS) for treatment of rheumatoid arthritis, which are influenced by circadian rhythm. Chronopharmaceutical drug delivery system is capable of delivering drug when and where drug required most. Naproxen would remain in the GIT Fluid, intestinal fluid and it will liberate only in colonic fluid and gives better absorption.
Methods: The matrix core tablets of Naproxen were prepared by direct compression method by using Crosspovidone as superdisintegrant. From those optimesd batch core tablet is further going for coating. Coating was carried out by using natural gums like Xanthan gum, Guar gum, Chitosan and Pectin alone and in combination.
Results: From the experimental work Crosspovidone shows good drug release. Coating done by combination of Xanthan Gum and Chitosan shows better drug release (98.24%) in sustained release manner than other natural gums like Guar gum and pectin.
Conclusion: From the results obtained, it was concluded that the programmable Chronopharmaceutical drug release has been achieved from Crosspovidone containing core tablet compressed coated by combination of Xanthan gum and Chitosan over a 10 hrs period, consistent with the demands of chronotherapeutic drug delivery for rheumatoid arthritis.
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