PLANT BASED QUORUM SENSING INHIBITORS OF PSEUDOMONAS AERUGINOSA
Keywords:
Pseudomonas aeruginosa, Phytochemicals, Quorum sensing, Anti-quorum sensing, anti-virulenceAbstract
Phytochemical research has gained a lot of momentum in the medical field for the discovery of new, safe, and effective remedies. In the context of antimicrobial research, various plant sources have been discovered with the potential to disrupt bacterial quorum sensing (QS), which plays a key role in the regulation of virulence in many Gram positive and Gram negative bacteria. Pseudomonas aeruginosa, a Gram negative bacterium, is known to produce multiple QS systems that control the expression of virulence determinants and biofilm development in this pathogen. Hence, the inhibition of QS has been pursued as a promising therapy for treatment of drug resistant Pseudomonas infections. A comprehensive review of the research data available for plant products as QS inhibitors of the organism has been presented here, while further suggesting the future prospects for these inhibitors.
Downloads
References
González JE, Keshavan ND. Messing with bacterial quorum sensing. J Microbiol Mol Biol Rev 2006;70(4):859-75.
Ryan RP, Dow JM. Diffusible signals and interspecies communication in bacteria. J Microbiology 2008;154:1845-58.
Henke JM, Bassler BL. Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi. J Bacteriol 2004;186(20):6902-14.
Federle MJ, Bassler BL. Interspecies communication in bacteria. J Clin Invest 2003;112(9):1291-9.
Duan K, Dammel C, Stein J, Rabin H, Surette MG. Modulation of Pseudomonas aeruginosa gene expression by host microflora through interspecies communication. J Mol Microbiol 2003;50(5):1477-91.
Rickard AH, Palmer Jr RJ, Blehert DS, Campagna SR, Semmelhack MF, Egland PG, et al. Autoinducer 2:a concentration-dependent signal for mutualistic bacterial biofilm growth. J Mol Microbiol 2006;60(6):1446-56.
Moss RB. Cystic fibrosis:pathogenesis, pulmonary infection, and treatment. J Clin Infect Dis 2012;21(4):839-49.
Gaynes R, Edwards JR, System NNIS. Overview of nosocomial infections caused by Gram-negative bacilli. J Clin Infect Dis 2005;41:848-54.
Rosenthal VD, Maki DG, Salomao R, Alvarez C, Mehta Y, Higuera F, et al. Device-associated nosocomial infections in 55 intensive care units of 8 developing countries. J Ann Intern Med 2006;145(8):582-91.
D’Agata E. Rapidly rising prevalence of nosocomial multidrug-resistant, Gram-negative bacilli:A 9-year surveillance study. J Infect Control Hosp Epidemiol 2004;25(10):842-6.
Strateva T, Mitov I. Contribution of an arsenal of virulence factors to pathogenesis of Pseudomonas aeruginosa infections. J Ann Microbiol 2011;61:717-32.
Lazdunski AM, Ventre I, Bleves S. Cell-cell communication:quorum sensing and regulatory circuits in Pseudomonas aeruginosa. In:Ramos J, Filloux A, editors. Pseudomonas. Volume 5. A model system in biology. Springer;2007;279-310.
Telford G, Wheeler D, Williams P, Tomkins PT, Appleby P, Swell H, et al. The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity. Infect Immun 1998;66(1):36-42.
Smith RS, Harris SG, Phipps R, Iglewski B. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J Bacteriol 2002;184(4):1132-9.
Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Cámara M. Quinolones:from antibiotics to autoinducers. J FEMS Microbiol Rev 2011;35:247-74.
Amara N, Krom BP, Kaufmann GF, Meijler MM. Macromolecular inhibition of quorum sensing:enzymes, antibodies, and beyond. J Chem Rev 2011;111:195-208.
Tateda K, Comte R, Pechere J-C, Köhler T, Yamaguchi K, Van Delden C. Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa. J Antimicrob Agents Chemother 2001;45(6):1930-3.
Bala A, Kumar R, Harjai K. Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections. J Med Microbiol 2011;60:300-6.
Delden C Van, Köhler T, Ferber FB, Franҫois B, Carlet J, Pechère J-C. Azithromycin to prevent Pseudomonas aeruginosa ventilator-associated pneumonia by inhibition of quorum sensing:a randomized controlled trial. J Intensive Care Med 2012;38(7):1118-25.
Chung J, Goo E, Yu S, Choi O, Lee J, Kim J, et al. Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase. J Proc Natl Acad Sci USA 2011;108(29):12089-94.
Churchill MEA, Chen L. Structural basis of acyl-homoserine lactone-dependent signaling. J Chem Rev 2011;111(1):68-85.
Givskov M, Nys R De, Manefield M, Gram L, Maximilien R, Givskov M, et al. Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling. J Bacteriol 1996;178(22):6618-22.
Müh U, Hare BJ, Duerkop BA, Schuster M, Hanzelka BL, Heim R, et al. A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal. Proc Natl Acad Sci USA 2006;103(45):16948-52.
Kim C, Kim J, Park H-Y, Park H-J, Lee JH, Kim CK, et al. Furanone derivatives as quorum-sensing antagonists of Pseudomonas aeruginosa. J Appl Microbiol Biotechnol 2008;80:37-47.
Cheoljin K, Kim J, Park H-Y, Mclean RJC, Kim CK, Jeon J, et al. Molecular modeling, synthesis, and screening of new bacterial quorum-sensing antagonists. J Microbiol Biotechnol 2007;17(10):1598-606.
Yang L, Rybtke MT, Jakobsen TH, Hentzer M, Bjarnsholt T, Givskov M, et al. Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors. J Antimicrob Agents Chemother 2009;53(6):2432-43.
Soulère L, Sabbah M, Fontaine F, Queneau Y, Doutheau A. LuxR-dependent quorum sensing:Computer aided discovery of new inhibitors structurally unrelated to N-acylhomoserine lactones. J Bioorg Med Chem Lett 2010;20:4355-8.
McRae J, Yang Q, Crawford R, Palombo E. Review of the methods used for isolating pharmaceutical lead compounds from traditional medicinal plants. J Environmentalist 2007;27:165-74.
Cowan MM. Plant products as antimicrobial agents. J Clin Microbiol Rev 1999;12(4):564-82.
Steindler L, Venturi V. Detection of quorum-sensing N-acyl homoserine lactone signal molecules by bacterial biosensors. J FEMS Microbiol Lett 2007;266:1-9.
Koh C-L, Sam C-K, Yin W-F, Tan LY, Krishnan T, Chong YM, et al. Plant-derived natural products as sources of anti-quorum sensing compounds. J Sensors 2013;13:6217-28.
Vattem DA, Mihalik K, Crixell SH, McLean RJC. Dietary phytochemicals as quorum sensing inhibitors. J Fitoterapia 2007;78:302-10.
Zahin M, Hasan S, Aqil F, Khan MSA, Husain FM, Ahmad I. Screening of certain medicinal plants from India for their anti-quorum sensing activity. Indian J Exp Biol 2010;48:1219-24.
Issac Abraham SVP, Palani A, Ramaswamy BR, Shunmugiah KP, Arumugam VR. Antiquorum sensing and antibiofilm potential of Capparis spinosa. J Arch Med Res 2011;42:658-68.
Chong YM, Yin WF, Ho CY, Mustafa MR, Hadi AH, Awang K, et al. Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity. J Nat Prod 2011;74(10):2261-4.
Krishnan T, Yin W-F, Chan K-G. Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa PAO1 by Ayurveda spice clove (Syzygium aromaticum) bud extract. J Sensors 2012;12:4016-30.
Tan LY, Yin W-F, Chan K-G. Silencing quorum sensing through extracts of Melicope lunu-ankenda. J Sensors 2012;12:4339-51.
Priya K, Yin W-F, Chan K-G. Anti-quorum sensing activity of the traditional Chinese herb, Phyllanthus amarus. J Sensors 2013;13:14558-69.
Brango-Vanegas J, Costa GM, Ortmann CF, Schenkel EP, Reginatto FH, Ramos FA, et al. Glycosylflavonoids from Cecropia pachystachya Trécul are quorum sensing inhibitors. J Phytomedicine 2014;21(5):670-5.
Delden C Van, Pesci EC, Pearson JP, Iglewski BH. Starvation selection restores elastase and rhamnolipid production in a Pseudomonas aeruginosa quorum-sensing mutant. J Infect Immun 1998;66(9):4499-502.
Adonizio AL. Anti-quorum sensing agents from South Florida medicinal plants and their attenuation of Pseudomonas aeruginosa pathogenicity. FIU Electron Theses Diss 2008;Paper 13.
Rasmussen TB, Bjarnsholt T, Skindersoe ME, Hentzer M, Kristoffersen P, Köte M, et al. Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. J Bacteriol 2005;187(5):1799-814.
Bjarnsholt T, Jensen PØ, Rasmussen TB, Christophersen L, Calum H, Hentzer M, et al. Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections. J Microbiology 2005;151:3873-80.
Jakobsen TH, van Gennip M, Phipps RK, Shanmugham MS, Christensen LD, Alhede M, et al. Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. J Antimicrob Agents Chemother 2012;56(5):2314-25.
Song Z, Kong KF, Wu H, Maricic N, Ramalingam B, Priestap H, et al. Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection. J Phytomedicine 2010;17:1040-6.
Song Z, Johansen HK, Faber V, Moser C, Kharazmi A, Rygaard J, et al. Ginseng treatment reduces bacterial load and lung pathology in chronic Pseudomonas aeruginosa pneumonia in rats. J Antimicrob Agents Chemother 1997;41(5):961-4.
Song Z, Kharazmi A, Wu H, Faber V, Moser C, Johansen HK, et al. Effects of Ginseng treatment on neutrophil chemiluminescence and immunoglobulin G subclasses in a rat model of chronic Pseudomonas aeruginosa pneumonia. J Clin Vaccine Immunol 1998;5(6):882-7.
Vandeputte OM, Kiendrebeogo M, Rajaonson S, Diallo B, Mol A, El Jaziri M, et al. Identification of catechin as one of the flavonoids from Combretum albiflorum bark extract that reduces the production of quorum-sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1. J Appl Environ Microbiol 2010;76(1):243-53.
Vandeputte OM, Kiendrebeogo M, Rasamiravaka T, Stévigny C, Duez P, Rajaonson S, et al. The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1. J Microbiology 2011;157:2120-32.
Sarabhai S, Sharma P, Capalash N. Ellagic acid derivatives from Terminalia chebula Retz. downregulate the expression of quorum sensing genes to attenuate Pseudomonas aeruginosa PAO1 virulence. J PLoS One 2013;8(1):e53441.
Taganna JC, Quanico JP, Perono RMG, Amor EC, Rivera WL. Tannin-rich fraction from Terminalia catappa inhibits quorum sensing (QS) in Chromobacterium violaceum and the QS-controlled biofilm maturation and LasA staphylolytic activity in Pseudomonas aeruginosa. J Ethnopharmacol 2011;134(3):865-71.
Jakobsen TH, Bragason SK, Phipps RK, Christensen LD, van Gennip M, Alhede M, et al. Food as a source for quorum sensing inhibitors:iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa. J Appl Environ Microbiol 2012;78(7):2410-21.
Ganin H, Rayo J, Amara N, Levy N, Krief P, Meijler MM. Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing. J Med Chem Commun 2013;4:175-9.
Rasamiravaka T, Jedrzejowski A, Kiendrebeogo M, Rajaonson S, Randriamampionona D, Rabemanantsoa C, et al. Endemic malagasy Dalbergia species inhibit quorum sensing in Pseudomonas aeruginosa PAO1. J Microbiology 2013;159:924-38.
Singh BN, Singh HB, Singh A, Singh BR, Mishra A, Nautiyal CS. Lagerstroemia speciosa fruit extract modulates quorum sensing-controlled virulence factor production and biofilm formation in Pseudomonas aeruginosa. J Microbiology 2012;158:529-38.
Annapoorani A, Kalpana B, Musthafa KS, Pandian SK, Veera Ravi A. Antipathogenic potential of Rhizophora spp. against the quorum sensing mediated virulence factors production in drug resistant Pseudomonas aeruginosa. J Phytomedicine 2013;20(11):956-63.
Musthafa KS, Ravi AV, Annapoorani A, Packiavathy ISV, Pandian SK. Evaluation of anti-quorum-sensing activity of edible plants and fruits through inhibition of the N-acyl-homoserine lactone system in Chromobacterium violaceum and Pseudomonas aeruginosa. J Chemotherapy 2010;56(4):333-9.
Gala V, John N, Desai K. Evaluation of the potential of five medicinal plants to inhibit acyl homoserine lactone based quorum sensing in Pseudomonas aeruginosa and Acinetobacter baumannii. Int J Pharm Bio Sci 2013;4(2):(B) 445-53.
Deptuła A, Gospodarek E. Reduced expression of virulence factors in multidrug-resistant Pseudomonas aeruginosa strains. J Arch Microbiol 2010;192(1):79-84.
Karatuna O, Yagci A. Analysis of quorum sensing-dependent virulence factor production and its relationship with antimicrobial susceptibility in Pseudomonas aeruginosa respiratory isolates. J Clin Microbiol Infect 2010;16(12):1770-5.
Schaber JA, Hammond A, Carty NL, Williams SC, Colmer-hamood JA, Burrowes BH, et al. Diversity of biofilms produced by quorum-sensing-deficient clinical isolates of Pseudomonas aeruginosa. J Med Microbiol 2007;56:738-48.
Pustelny C, Albers A, Büldt-Karentzopoulos K, Parschat K, Chhabra SR, Cámara M, et al. Dioxygenase-mediated quenching of quinolone-dependent quorum sensing in Pseudomonas aeruginosa. J Chem Biol 2009;16:1259-67.
Lu C, Kirsch B, Zimmer C, de Jong JC, Henn C, Maurer CK, et al. Discovery of antagonists of PqsR, a key player in 2-alkyl-4-quinolone-dependent quorum sensing in Pseudomonas aeruginosa. J Chem Biol 2012;19:381-90.
Teplitski M, Robinson JB, Bauer WD. Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density-dependent behaviors in associated bacteria. J Mol Plant-Microbe Interact 2000;13(6):637-48.