ANTIFUNGAL SUSCEPTIBILITY OF CRYPTOCOCCUS NEOFORMANS ISOLATES FROM FUNGAL MENINGITIS IN AIDS PATIENTS IN INDIA
Keywords:
Antifungal susceptibility, Cryptococcal meningitis, HIV, India, MICsAbstract
Objectives: This study was undertaken to determine the antifungal susceptibility of fifteen cryptococcal isolates from cerebrospinal fluid (CSF) of HIV seropositive patients with cryptococcal meningitis.
Methods: Antifungal susceptibility testing of the isolates was done by CLSI M27 A-3 methodology for amphotericin B, fluconazole, voriconazole, itraconazole and 5-flucytosine.
Results: Our study demonstrates no evidence of resistance among clinical isolates of Cryptococcus neoformans for any of the above mentioned antifungal drugs. Only two isolates showed slightly higher minimum inhibitory concentration (MIC) to 5-flucytosine (8 µg/ml).
Conclusion: Routine In vitro antifungal susceptibility for cryptococcal isolates is important, in order to obtain a baseline data and to predict any shift in the susceptibility patterns in the Indian population.
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References
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