PREPARATION AND EVALUATION OF FLOATING EXTENDED RELEASE MATRIX TABLET USING COMBINATION OF POLYMETHACRYLATES AND POLYETHYLENE OXIDE POLYMERS

Authors

  • Balamurugan Jeganathan Research Scholar, Department of Pharmacy, Jawaharlal Nehru Technological University Hyderabad, Andhra Pradesh, India. Matrix Laboratories Limited, R&D Center, Bollaram Village, Medak Dist.
  • Vijayalakshmi Prakya Department of Pharmaceutics, Vijaya College of Pharmacy, Munganoor (v), Hayathnagar (M), Hyderabad 501511 Andhra Pradesh, India

Keywords:

Floating, Extended Release, Polymethacrylates, Polyethylene oxide

Abstract

Objective: The purpose of this study was to prepare non-effervescent floating extended release matrix of Tramadol hydrochloride using polyethylene oxide (PEO) and a combination of cationic and anionic polymethacrylates polymers, Eudragit® EPO (EE) and Eudragit® L100-55 (EL).

Methods: Polymethacrylate polymer mixtures (PPM) in different polymer weight ratios (1:2, 1:1 and 2:1) were prepared by hot melt mixing process. Thermally treated PPM were evaluated by differential scanning calorimetry and fourier transform infrared spectroscopy for possible interpolyelectrolyte complex formation. The formulation variables like effects of polymethacryate ratios and their concentration, polymer types, PEO concentrations and compression force on release characteristics were investigated. The tablets were also evaluated for physicochemical properties,in vitro floating ability (floating lag-time and duration) and swelling properties.

Results: The optimized formulation with the combination of PEO and PPM (F4) showed instant floating properties, extended drug release properties for 14h and tablet remained buoyant for >24 h. Significant difference was observed in the effect of pH of dissolution media on drug release from formulations prepared using combination of PEO and PPM. The dissolution data of these matrices were fitted to different dissolution models. Non- Fickian release transport was confirmed as the drug release mechanism from the optimized formulation (F4).

Conclusion: non- effervescent floating tablets were found a feasible approach for the sustained-release preparation of drugs, which have limited absorption sites in the stomach

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Published

31-08-2014

How to Cite

Jeganathan, B., and V. Prakya. “PREPARATION AND EVALUATION OF FLOATING EXTENDED RELEASE MATRIX TABLET USING COMBINATION OF POLYMETHACRYLATES AND POLYETHYLENE OXIDE POLYMERS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 584-92, https://journals.innovareacademics.in/index.php/ijpps/article/view/2762.

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