CHITOSAN NANOPARTICLES AS A NASAL DRUG DELIVERY FOR MEMANTINE HYDROCHLORIDE
Keywords:
Chitosan, Memantine hydrochloride, Nanoparticles, TripolyphosphateAbstract
Objective: The aim of the present study is to prepare crosslinked chitosan nanoparticles of memantine hydrochloride by using ionic gelation for nasal drug delivery system.
Methods: The Memantine Hydrochloride loaded chitosan nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions (TPP). Various trials have been carried out to optimize the particle size, polydispersiblity index and zeta potential. The different concentration of chitosan to TPP of 2:1,3:1,4:1,5:1with varying the stirring time 2 hrs,4 hrs,6 hrs,8 hrs and stirring speed 500 rpm, 1000 rpm, 1500 rpm, 2000 rpm were used to prepare the memantine loaded chitosan nanoparticle was prepared.
Results: The effects, including chitosan concentration, stirring speed and stirring time on the physicochemical properties of the nanoparticle, such as particle size, polydispersibility index was studied
Conclusion: The formulation was optimized for the particle size and polydispersibility index and the particle size of nanoparticle was found to be 129 nm at 4 hrs of stirring times, 1000 rpm of stirring speed and 2:1concentration ratio of chitosan and TPP. Memantine loaded chitosan nanoparticle is a potential new delivery system for treatment of Alzheimer's disease, when transported via olfactory nasal pathway to the brain.
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