PHARMACOKINETIC STUDIES OF NEW SILVER-BASED COMPLEX
Keywords:
Silver-based complex, Pharmacokinetics, Antiviral drug, Silver distribution in tissues, Mass spectrometry, ArgosilAbstract
Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called Argosilâ€, with high antiviral activity.
Methods: Water solution of complex administered intragastrically in the dose rate of 100 mg/kg body weight of mice BALB/c (males) aged 1.5-2.0 mo. Blood and tissues samples analyzed by mass spectrometry.
Results: Half-life of the drug was about 4 h at the initial stage. About 5% of the initially introduced silver detected after 24 h. Maximum drug concentration observed in the lung tissues.
Conclusion: Results make the basis for further test and clinical implementation. Taken into account low toxicity and antiviral properties of this compound, it looks especially effective for lung infections treatment.
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References
Lansdown AB. Pharmacological and toxicological profile of silver as an antimicrobial agent in medical devices. Adv Pharm Sci 2010;2010:1-16.
Bachler G, von Goetz N, Hungerbühler K. A physiologically based pharmacokinetic model for ionic silver and silver nanoparticles. Int J Nanomedicine 2013;8:3365-82.
Tikhonov VL, Donchenko AS, Glotovo TI, Silnikov VN, Tretyakov VV. Toxicity and antiviral activity of the new drug on the basis of silver Argobiotsin-2S. Siberian herald agricultural science (Rus) 2007;12:55-60.
Agilent 7500 ICP-MS Chemstation operation G3270-90111. Tokyo: Yokagawa Analitical Systems Inc; 2004:74.
Solovyev VN, Firsov AA, Filobbb v VA. Pharmacokinetics. Moscow: Medicine; 1980. p. 424.
Khabriev RW. Manual on experimental (preclinical) study of new pharmacological substances. Moscow: Medicine; 2005. p. 832.