ANALYTICAL APPLICATION OF E.B.T IN SPECTRPHOTOMETRIC DETERMINATION OF ELETRIPTAN HYDROBROMIDE
Abstract
A simple and sensitive spectrophotometric method has been developed for the estimation of Eletriptan Hydrobomide (EHB).The method is based on the formation of ion-association complex with EHB with acid dye, E.B.T. The cationic form of the dye E.B.T involves in the formation of neutral coloured ion-association complex  with negative charge (acid groups in the drug) which is extractable into chloroform and behaves as a single unit being held together by electrostatic attraction. The absorption maxima were found to be at lMax 510nm. The method obeys Beer's law within the limits 40-240µg/ml and gives reproducible results. Molar absorptivity value is obtained as 1.2116 x 105 L mol-1 cm-1 and recovery was found to be 99.806 to 99.742. Interferences of the other ingredients and excipients were not observed. The proposed method can be used for the determination of EHB both in pure and pharmaceutical formulations.
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