Harikesh Maurya, Susheel Kumar Dubey, Poonam Bisht, Monika Semwal, Sanjay Gandhi


Acquired immune deficiency syndrome, chronic obstructive pulmonary disease (COPD), cancer and immune suppressive agent initiate sepsis, following chronic situation change in to septic shock. Sepsis is responsible for nearly 30% of the total neonatal deaths each year in developing countries. About 96% of infants had survived up to their first year of life, and 56% infant deaths took place within the first month after birth. Firstly, symptoms observed as abnormal body temperature, bradycardia, tachypnoea which needs common treatments for survival. Apoptosis, decreased anti insulin hormone, abnormalities in coagulation, fibrinolysis and immune suppressant are responsible for the generation of inflammation which induces sepsis and leads to dysfunction of vital organs such as; GIT, brain, kidney, liver, cardiac and other organs dysfunction. Treatment in sepsis include antibiotics to suppress the infection, fluids and medicines through i.v. to maintain the blood pressure and stabilize blood circulation, while oxygen, plasma or blood products which correct any clotting problems. The fluid therapy in severe sepsis, corticosteroids, nutrition, vasopressors, ionotropic therapy, selenium, bicarbonate therapy, deep vein thrombosis prophylaxis, stress ulcer prophylaxis, administration of immunoglobulins and renal replacement therapy are mandatory in chronic conditions.

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