International Journal of Applied Pharmaceutics
Vol 1 Issue 1, 2009
ADVANCES IN VACCINATION: A REVIEW
SWARNALI DASa*, ROHITAS DESHMUKHb,
aSchool of Pharmacy and
bSri Shankaracharya Institute
of Pharmacy, Durg,
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The search for methods of vaccine delivery not requiring a needle and syringe has been accelerated by recent concerns regarding pandemic disease, bioterrorism, and disease eradication campaigns. In this article, we summarize the rationale behind the advances of vaccination techniques. Needle-free vaccine delivery could aid in these mass vaccinations by increasing ease and speed of delivery, and by offering improved safety and compliance, decreasing costs, and reducing pain associated with vaccinations. Needle-free vaccination includes all methods for delivering vaccines that do not require a needle and syringe for administration.
New and promising technologies include using live attenuated bacteria as vectors for foreign antigens and transgenic plant “edible” vaccines. Both nasal and aerosol vaccines are easy to deliver and are painless. Many of the technologies described here require further clinical studies to ensure safety and efficacy, but they still offer promising vaccine delivery methods.
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