• M Gayathri
  • Gayathri Ga


Glucose is a key fuel in mammalian cells that import by a process of facilitative diffusion mediated by glucose transporters (GLUT). A defect in GLUT
expression for prolong time leads to diabetes mellitus. Medicinal plants used in traditional treatments confirm a possibility of tackling diabetes by
regulating the GLUT activity in the body, with lesser side effects. Resistant of tissues to insulin is a major manifestation in type 2, and the cause can be
localized in defect of glucose that can be reverse by medicinal plants. In vitro, in vivo, and in silico studies of plant extracts and its active compounds
support for their multiple target mechanisms. Many medicinal plants used in the traditional medicine enhancing the translocation of GLUT and this
could lead to a new approach for treating type 2 diabetes.
Keywords: Diabetes, Glucose transporters, Mechanism of glucose transporter, Glucose transporters 4, Medicinal plants.



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Table 1: (Contd...)
Glucose uptake in C2C12 skeletal muscle increased by these plants through AMPK
signaling pathway in 18 hrs of treatment. Phosphorylation of AMPK and ACC were
increased up to 2.5- and 3.5-fold, respectively. The AMPK
Pathway converges with the insulin receptor pathway at the level of AS160 and
in this way can induce the translocation of GLUT4 GLUTs to the sarcolemma and
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Tamarindus indica Aqueous seed extract Quantitative reverse transcription-PCR results showed increase in muscle GLUT4
mRNA and liver SREBP-1c mRNA concentrations of diabetic treated rats [36]
Pterocarpus marsupium Isoflvone Isoflavone of this plant exert the same glucose transport activity in an alternate
mechanism; PPAR mediated by PI3 kinase-independent manner in adipocytic
cell-line 3T3-L1 [37]
Cornus kousa Results showed that increases the GLUT4 translocation through increased insulin
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Persea americana Hydroalcoholic extract The extract regulates glucose uptake in liver and muscles by the activation of
PKB/Akt [39]
Fermented tea extract It activates both PI3K/Akt- and MPK-dependent signaling pathways to induce
GLUT4 translocation and increases the expression of insulin receptor to improve
glucose intolerance [40]
Pine bark extract In vitro the results proved that the extract acts by activating p38 mitogen-activated
kinase, which in turn activates SGLT1 transporters [41]
Cecropia obtusifolia Aqueous extract Activates the insulin signaling pathway and translocate GLUTs [42]
Lyophyllum decastes Aqueous extract Increases the translocation of GLUT4 in the plasma membrane [43]
Liriope platyphylla Homoisoflvone Stumulates IRS - phosphatidyl inositol 3 kinase-Akt signaling mechanism [44]
Andrographis paniculata andrographolide In vivo studies show higher expression of GLUT4 [45]
Azadirachta indica Hydroalcoholic extract Increases the glucose uptake through cascade events in adipose and skeletal
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Musa sapientum Docking study in Autodock 4 software shows hypoglycemic activity; improve
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Helicteres isora Fruits Docking studies in Autodock 4 show potent antidiabetic activity against type 2
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GLUT: Glucose transporter, GA: Galli acid, CND: Cinnamaldehyde, PCR: Polymerase chain reaction, mRNA: Messenger RNA, 4-HPA: 4-hydroxypipecolic acid, IRS: Insulin
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How to Cite
Gayathri, M., and G. Ga. “REVIEW ON ENHANCEMENT OF GLUCOSE UPTAKE AND UP-REGULATION OF GLUCOSE TRANSPORTERS BY ANTIDIABETIC MEDICINAL PLANTS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 2, Mar. 2016, pp. 34-39,
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