The electro-oxidation of nimesulide has been investigated by cyclic and differential-pulse voltammetry at different pH at gold electrode. Cyclic voltammetric studies were performed in a wide range of sweep rates and various concentrations of nimesulide. The oxidation process was irreversible and exhibited a diffusion-controlled behavior. According to the linear relation between the peak current and the nimesulide concentration, differential-pulse voltammetric method for the quantitative determination in pharmaceuticals was developed. The recovery was determined to be 97.3 to 100.2 % by means of standard addition method. The linear response was obtained in the range of 2.0 x 10-7 to 1.2 x 10-6 M with a detection limit of 1.11 x 10-9 M with good selectivity and sensitivity. The electrochemical behaviors of nimesulide were studied and electron-transfer coefficient (α = 0.5), proton number (X = 1) and electron transfer number (n = 2) have been determined. The proposed method was also applied for the detection of nimesulide in urine as a real sample.

Keywords: Nimesulide; Gold electrode; Electrochemical behavior; Drug analysis


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How to Cite

J. MALODE, S., and S. T. NANDIBEWOOR. “ELECTRO-OXIDATION OF NIMESULIDE AT GOLD ELECTRODE AND ITS DETERMINATION IN PHARMACEUTICAL DOSAGE FORM AND HUMAN BIOLOGICAL FLUID”. Asian Journal of Pharmaceutical and Clinical Research, vol. 6, no. 3, July 2013, pp. 71-76, https://innovareacademics.in/journals/index.php/ajpcr/article/view/109.