A CORRELATIVE STUDY OF THYROID PROFILE AND MINERAL STATUS IN PATIENTS WITH HYPOTHYROIDISM - A HOSPITAL BASED CASE CONTROL STUDY


Susanna T Y, Sagayaraj A, Shashidhar K N, Gomathi M, Mahesh V

Abstract


Objective: To evaluate the alteration in mineral status by estimating serum calcium, phosphorus, and magnesium in hypothyroid patients compared
to healthy volunteers and its correlation with thyroid profile (triiodothyronine [T3], thyroxine [T4], and thyroid stimulating hormone [TSH]).
Methods: Blood samples were collected from 30 hypothyroid patients and 30 healthy volunteers and analyzed for serum levels of calcium, magnesium,
and phosphorus and for thyroid profile.
Results: There were 22 females and 8 males in the hypothyroid patients group and 24 females and 6 males in the control group. The mean age in
the two groups was 39±13. The study observed a significantly decreased levels of serum magnesium, significantly increased serum phosphorus
and serum creatinine levels among hypothyroid patients as compared to the control group (p<0.001), respectively, serum calcium levels did not
show a significant change in hypothyroid patients compared to the control group. Among hypothyroid subjects, there was a significant positive
correlation of T3 and T4 with serum magnesium and a negative correlation of T4 with serum phosphorus and serum creatinine. TSH showed a
positive correlation with serum phosphorus and serum creatinine and a negative correlation with serum magnesium. However, T3, T4, and TSH did
not show any correlation with serum calcium levels.
Conclusion: The direction of effect of overt hypothyroidism on the blood levels of calcium, magnesium, and phosphorus is inconsistent affecting the
various metabolisms and clinical manifestations; in these patients, hence all patients with overt hypothyroidism need to be evaluated for mineral
status to provide individualized holistic disease management strategies to these patients.
Keywords: Hypothyroidism, Calcium, Magnesium, Phosphorus.


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References


Mariani LH, Berns JS. The renal manifestations of thyroid disease.

J Am Soc Nephrol 2012;23(1):22-6.

Schwarz C, Alexander BL, Spiros A, Georg MF, Heinz Z,

Aristomenis KE, et al. Thyroid function and serum electrolytes: Does

an association really exist? Eur J Med Sci 2012;142:w13669.

Farnsworth AE, Dobyns BM. Hypercalcaemia and thyrotoxicosis.

Med J Aust 1974;2(21):782-4.

Shivaleela MB, Poornima RT, Murthy DS. Serum calcium and

phosphorus levels in thyroid dysfunction. Indian J Fundam Appl Life

Sci 2012;2(2):179-83.

Alcalde AI, Sarasa M, Raldúa D, Aramayona J, Morales R, Biber J,

et al. Role of thyroid hormone in regulation of renal phosphate transport

in young and aged rats. Endocrinology 1999;140(4):1544-51.

Sabuncu T, Aksoy N, Arikan E, Ugur B, Tasan E, Hatemi H. Early

changes in parameters of bone and mineral metabolism during

therapy for hyper - and hypothyroidism. Endocr Res 2001;27(12):203-13.

Kavitha MM, Chandrashekharyya SH, Kashinakunti SV, Sunitha H,

Neela BM, Ratna S. Alteration in levels of serum calcium, phosphorus

and magnesium in patients of hypothyroidism. Int J Biol Med Res

;5(4):4594-6.

Gohel MG, Shah AM, Shah AM, Makadia JS. A study of serum calcium,

magnesium and phosphorus level in hypothyroidism patients. Int J Med

Health Sci 2014;3(4):308-12.

Nisa F, Mumtaz A, Ullah MI, Atif M, Sami W. Determination of serum

zinc and magnesium levels in patients with hypothyroidism. Trace

Elem Electrolytes 2013;15:1-5.

Frizel D, Malleson A, Marks V. Plasma levels of ionised calcium and

magnesium in thyroid disease. Lancet 1967;1(7524):1360-1.

Bharti A, Shrestha S, Rai A, Singh MK. Assessment of serum minerals

and electrolytes in thyroid patients. Int J Adv Sci Res 2015;1(6):259-63.

Suneel B, Nagendra DR, Aparna RR, Balakrishna D, Naidu JN. Mineral

status in thyroid disorders (hypo and hyper). Int J Appl Biol Pharm

Technol 2011;2(4):423-9.

Abdel-Gayoum AA. Dyslipidemia and serum mineral profiles in

patients with thyroid disorders. Saudi Med J 2014;35(12):1469-76.




About this article

Title

A CORRELATIVE STUDY OF THYROID PROFILE AND MINERAL STATUS IN PATIENTS WITH HYPOTHYROIDISM - A HOSPITAL BASED CASE CONTROL STUDY

Date

01-05-2016

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 9 Issue 3 (May-June) 2016 Page: 292-294

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

176 Views | 525 Downloads

Authors & Affiliations

Susanna T Y
Department of Biochemistry Sri Devaraj Urs Medical college & Research Centre Tamaka,Kolar Karnataka 563102
India

Sagayaraj A
Associate Professor Department Of Otorhinolaryngology Sri Devaraj Urs Medical College and Research centre. Tamaka,Kolar Karnataka : 563101
India

Shashidhar K N
Prof & HOD Department of Biochemistry Sri Devaraj Urs Medical College and Research centre. Tamaka,Kolar Karnataka : 563101
India

Gomathi M
6th Semester MBBS Student Sri Devaraj Urs Medical College and Research centre. Tamaka, Kolar Karnataka : 563101
India

Mahesh V
Assistant Professor Department of Community Medicine Sri Devaraj Urs Medical College and Research centre. Tamaka, Kolar, Karnataka : 563101


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