A CORRELATIVE STUDY OF THYROID PROFILE AND MINERAL STATUS IN PATIENTS WITH HYPOTHYROIDISMÂ -Â AÂ HOSPITALÂ BASEDÂ CASEÂ CONTROLÂ STUDY
Objective: To evaluate the alteration in mineral status by estimating serum calcium, phosphorus, and magnesium in hypothyroid patients compared
to healthy volunteers and its correlation with thyroid profile (triiodothyronine [T3], thyroxine [T4], and thyroid stimulating hormone [TSH]).
Methods: Blood samples were collected from 30 hypothyroid patients and 30 healthy volunteers and analyzed for serum levels of calcium, magnesium,
and phosphorus and for thyroid profile.
Results: There were 22 females and 8 males in the hypothyroid patients group and 24 females and 6 males in the control group. The mean age in
the two groups was 39Â±13. The study observed a significantly decreased levels of serum magnesium, significantly increased serum phosphorus
and serum creatinine levels among hypothyroid patients as compared to the control group (p<0.001), respectively, serum calcium levels did not
show a significant change in hypothyroid patients compared to the control group. Among hypothyroid subjects, there was a significant positive
correlation of T3 and T4 with serum magnesium and a negative correlation of T4 with serum phosphorus and serum creatinine. TSH showed a
positive correlation with serum phosphorus and serum creatinine and a negative correlation with serum magnesium. However, T3, T4, and TSH did
not show any correlation with serum calcium levels.
Conclusion: The direction of effect of overt hypothyroidism on the blood levels of calcium, magnesium, and phosphorus is inconsistent affecting the
various metabolisms and clinical manifestations; in these patients, hence all patients with overt hypothyroidism need to be evaluated for mineral
status to provide individualized holistic disease management strategies to these patients.
Keywords: Hypothyroidism, Calcium, Magnesium, Phosphorus.
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