A CORRELATIVE STUDY OF THYROID PROFILE AND MINERAL STATUS IN PATIENTS WITH HYPOTHYROIDISM - A HOSPITAL BASED CASE CONTROL STUDY

  • Susanna T Y Department of Biochemistry Sri Devaraj Urs Medical college & Research Centre Tamaka,Kolar Karnataka 563102
  • Sagayaraj A Associate Professor Department Of Otorhinolaryngology Sri Devaraj Urs Medical College and Research centre. Tamaka,Kolar Karnataka : 563101
  • Shashidhar K N Prof & HOD Department of Biochemistry Sri Devaraj Urs Medical College and Research centre. Tamaka,Kolar Karnataka : 563101
  • Gomathi M 6th Semester MBBS Student Sri Devaraj Urs Medical College and Research centre. Tamaka, Kolar Karnataka : 563101
  • Mahesh V Assistant Professor Department of Community Medicine Sri Devaraj Urs Medical College and Research centre. Tamaka, Kolar, Karnataka : 563101

Abstract

Objective: To evaluate the alteration in mineral status by estimating serum calcium, phosphorus, and magnesium in hypothyroid patients compared
to healthy volunteers and its correlation with thyroid profile (triiodothyronine [T3], thyroxine [T4], and thyroid stimulating hormone [TSH]).
Methods: Blood samples were collected from 30 hypothyroid patients and 30 healthy volunteers and analyzed for serum levels of calcium, magnesium,
and phosphorus and for thyroid profile.
Results: There were 22 females and 8 males in the hypothyroid patients group and 24 females and 6 males in the control group. The mean age in
the two groups was 39±13. The study observed a significantly decreased levels of serum magnesium, significantly increased serum phosphorus
and serum creatinine levels among hypothyroid patients as compared to the control group (p<0.001), respectively, serum calcium levels did not
show a significant change in hypothyroid patients compared to the control group. Among hypothyroid subjects, there was a significant positive
correlation of T3 and T4 with serum magnesium and a negative correlation of T4 with serum phosphorus and serum creatinine. TSH showed a
positive correlation with serum phosphorus and serum creatinine and a negative correlation with serum magnesium. However, T3, T4, and TSH did
not show any correlation with serum calcium levels.
Conclusion: The direction of effect of overt hypothyroidism on the blood levels of calcium, magnesium, and phosphorus is inconsistent affecting the
various metabolisms and clinical manifestations; in these patients, hence all patients with overt hypothyroidism need to be evaluated for mineral
status to provide individualized holistic disease management strategies to these patients.
Keywords: Hypothyroidism, Calcium, Magnesium, Phosphorus.

Author Biographies

Susanna T Y, Department of Biochemistry Sri Devaraj Urs Medical college & Research Centre Tamaka,Kolar Karnataka 563102

Dr Susanna TY.

MBBS,MD,PGDGT

Assistant professor

Department of Biochemistry

Sagayaraj A, Associate Professor Department Of Otorhinolaryngology Sri Devaraj Urs Medical College and Research centre. Tamaka,Kolar Karnataka : 563101

Dr Sagayaraj. A

MBBS,MS

Associate Professor

Department Of Otorhinolaryngology

Sri Devaraj Urs Medical College and Research centre.

Tamaka,Kolar

Karnataka : 563101

Shashidhar K N, Prof & HOD Department of Biochemistry Sri Devaraj Urs Medical College and Research centre. Tamaka,Kolar Karnataka : 563101
Dr Shashidhar KNProf & HODDepartment of BiochemistrySri Devaraj Urs Medical College and Research centre.Tamaka,Kolar
Gomathi M, 6th Semester MBBS Student Sri Devaraj Urs Medical College and Research centre. Tamaka, Kolar Karnataka : 563101

Gomathi.M

6th Semester MBBS Student

Sri Devaraj Urs Medical College and Research centre.

Tamaka, Kolar

Karnataka : 563101

Mahesh V, Assistant Professor Department of Community Medicine Sri Devaraj Urs Medical College and Research centre. Tamaka, Kolar, Karnataka : 563101

Dr.Mahesh.V 

MBBS,MD

Assistant Professor

Department of Community Medicine

Sri Devaraj Urs Medical College and Research centre.

Tamaka, Kolar, Karnataka : 563101

 

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How to Cite
T Y, S., S. A, S. K N, G. M, and M. V. “A CORRELATIVE STUDY OF THYROID PROFILE AND MINERAL STATUS IN PATIENTS WITH HYPOTHYROIDISM - A HOSPITAL BASED CASE CONTROL STUDY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 3, May 2016, pp. 292-4, https://innovareacademics.in/journals/index.php/ajpcr/article/view/11343.
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