IS THERE TREATMENT EFFECT OF VINPOCETINE ON AUTONOMIC DYSFUNCTION IN RATS WITH ALZHEIMER


Azizuddin Khan, Nazan Dolu, Seda Gündüz, Ali Yucel Kara, Hale Acer, Selda Tasa

Abstract


Alzheimer's disease (AD) shows less autonomic dysfunction. There was lack of response or prolongation of its latency in skin sympathetic response. Vinpocetine is a classic inhibitor of PDE1 activity. Vinpocetine treatment has been shown to enhance performance on cognitive tests in humans. The efficacy of the use of vinpocetine in clinical trials has been controversial. A comparison of multiple studies evaluating vinpocetine use in Alzheimer's disease  AD was recently conducted. Objective: Our first aim was to assess dysautonomia in rat with Alzheimer's disease  AD electrophysiologically, using sympathetic skin response (SSR) test. The second aim in this study, evaluate of the effect of vinpocetine treatment on Alzheimer autonomic dysfunction and attention deficiency.

Method: Rats were divided into four groups: Sham group (Group C, i.p. saline), Alzheimer group (Group A), Vinpocetine group (Group V, 5mg/kg, every other day, i.p.), Alzheimer+ Vinpocetine group (Group AV). Alzheimer's disease was induced in old male rats by AlCl3 (40 mg/kg i.p.) and D-Galactose (90 mg/kg) daily for 6 weeks. Then Skin Conductance Level (SCL), which is a sympathetic skin response parameter, was measured as tonic (no-stimuli period, 2 min) and phasic SSR (simultaneously with 15 auditory stimuli, 10 min). Tonic SSR is useful to investigate general states of arousal and alertness, while phasic SSR is useful to study multifaceted attentional processes (related to novelty, intensity). Results: SCL was difference among groups (tonic: F=21.47, p≤0.000; phasic: F=9.86, p≤0.000). Skin conductance level (SCL) was statistically lower in Group A than Group C (p≤0.005) and Group V (p≤0.000). SCL of Group V was statistically higher then Group C (p≤0.04), Group A (p≤0.000) and Group AV (p≤0.000). SCL of Group AV was lower than Group C’s (p≤0.01). Conclusion: There were no statistically difference between Group A and Group AV. We concluded that autonomic disturbances accompanied Alzheimer's disease and vinpocetine treatment couldn’t ameliorate this disturbance.

 

Keywords: Autonomic dysfunction, Dysautonomia, Inhibitor, Skin conductance level, Sympathetic skin response  


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About this article

Title

IS THERE TREATMENT EFFECT OF VINPOCETINE ON AUTONOMIC DYSFUNCTION IN RATS WITH ALZHEIMER

DOI

10.22159/ajpcr.2017.v10i2.11367

Date

01-02-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 2 February 2017 Page: 89-91

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

133 Views | 109 Downloads

Authors & Affiliations

Azizuddin Khan
Indian Institute of Technology Bombay
India

Nazan Dolu

Seda Gündüz

Ali Yucel Kara

Hale Acer

Selda Tasa


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