D-AMINO ACID OXIDASE: A REVIEW

Authors

  • Nithya S Vels University
  • Shanmugarajan Ts

Abstract

ABSTRACT
Over many years, D-serine and glycine were found to be the endogenous ligands for glycine-binding site for N-methyl-D-aspartate receptors. D-serine
before being used up by the cells undergoes oxidative deamination by the enzyme D-amino acid oxidase (DAAO) and makes D-serine levels reduced in
the brain, thereby affecting brain functions. In this review, we will discuss about the synthesis, location, therapeutic potential of DAAO function, role
in cognition, and neuropathic pain.
Keywords: D-serine, Glycine, N-methyl-D-aspartate receptors, D-amino acid oxidase, Cognition, Neuropathy.

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Published

2016-07-01

How to Cite

Nithya S, and S. Ts. “D-AMINO ACID OXIDASE: A REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 4, July 2016, pp. 33-36, https://innovareacademics.in/journals/index.php/ajpcr/article/view/11719.

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Section

Review Article(s)