A COMPREHENSIVE REVIEW ON NOVEL MICROSPONGES DRUG DELIVERY APPROACH

Abstract

ABSTRACT
Microsponges drug delivery approach (MDA) has been introduced in topical products to facilitate the controlled and targeted release of active
drug into the skin to decrease systemic exposure and minimize local cutaneous reaction. Microsponges are highly cross-linked, polymeric sponge,
porous in nature, spherical shape consisting of high drug content within their interconnecting voids, releasing bioactive agent at a target site within
predetermined time. They are mostly used for prolonged topical administration, enhanced efficacy for topically therapeutic agent with safety, stability
and reduced side effects followed by improved aesthetic properties in an efficient and novel manner. More ever, it is found to be stable over wide pH
range and compatible with most vehicles. We here complied recent data regarding properties of microsponges, their methodology pharmaceutical
application and list of patent till date.
Keywords: Microsponges, Bioactive, Porous, Interconnecting voids, Aesthetic.