EFFECT OF YOHIMBINE ON CLOMIPRAMINE-INDUCED SEXUAL DYSFUNCTION IN MALE RATS
Object: The present investigation has been carried out to find out the effect of yohimbine on clomipramine-induced sexual dysfunction in male rats.
Methods: The male rats were treated with clomipramine and yohimbine simultaneously for 60 days. During the treatment, all the male rats were
challenged with the female rats which are in estrous phase and their sexual behavior was observed under dim red light. Half of the animals in eachÂ group and remaining on 60Â day were sacrificed, blood was collected and serum separated. Testis was collected and preserved in 10% formalin for
subsequent histopathological examination.Â th
Results: The study reveals that yohimbine failed to antagonize the clomipramine-induced sexual dysfunction in male rats in all aspects, except the
partial improvement in the sexual behavior.
Conclusion: Yohimbine a well-known aphrodisiac failed to antagonize the clomipramine-induced sexual dysfunction in male rats. The decrease in
testosterone levels, a decrease in spermatozoa count were continued even in the presence of yohimbine except improvement in the sexual behavior
parameters. Hence, yohimbine could not be a safe antidote against clomipramine-induced sexual dysfunction in male rats.
Keywords: Yohimbine, Clomipramine, Testosterone, Male rat sexual competence, Testicular damage.
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