THE POTENTIAL IMPACTS OF THE ANTI-EPILEPTIC DRUG (OXCARBAZEPINE) ON ALBINO RAT'S NEONATES DURING LACTATION
Objective: This study was undertaken to evaluate the potential risks of the anti-epileptic drug (oxcarbazepine [OXC]) administration on neonates.
Methods: The nursing rats orally administered from 7
day of gestation until the 28
day of lactation with 108 mg/kg OXC (human equivalent dose)
daily. The neonates at day 7, 14, 21, and 28 of lactation were sacrificed and the postnatal developmental signs and skeletal malformation and the
histopathology of liver, kidney, and brain of the pups were examined.
Results: Our results showed that OXC induced a significant reduction in the neonatal weight and length, delayed, weak and incomplete ossification,
wavy ribs and the neonatal liver revealed histopathological changes, pyknotic hepatocytes, cytoplasmic vacuolization, dilated sinusoid, and necrotic
area. Kidney revealed alternation changes, enlargement of the glomerulus, renal tubules degeneration, and lymphatic infiltration. Brain (cerebral
cortex and cerebellum) showed neurodegenerative changes, vacuolization of neuropil, congested and dilated blood vessel and dark stain neurons.
Biochemical studies showed that OXC induced a reduction in the level glutathione reduced an important intracellular antioxidant, and catalase
(enzymatic antioxidant) compared to control group.
Conclusions: We support and proof the potential risks of the OXC administration on neonates.
Keywords: Rats, Lactation, Oxcarbazepine, Antiepileptic drug.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.