ISOLATION AND CHARACTERIZATION OF N-HEPTACOSANYL OLEATE FROM THE WHOLE AERIAL PARTS OF CENTELLA ASIATICA LINN.
Various studies have already been performed involving the whole aerial parts of Centella asiatica (L.) (Umbelliferae), commonly known as gotu kola or
jalbrahmi, and thus, the present investigation has been carried out for the phytochemical study of an ethanolic extract of the aerial parts of C. asiatica.
To perform this activity, the drug (1.5 kg) was exhaustively extracted in 95% ethanol using Soxhlet apparatus. The column chromatography was
performed then for isolating the various phytoconstituents using the solvents of increasing polarity from petroleum ether to methanol. The isolated
compounds were structurally elucidated using various spectral data analysis, i.e. infrared,1H nuclear magnetic resonance (NMR),13C NMR, and positive
ion fast atom bombardment mass spectrometry. One of the isolated compounds was characterized as n-heptacosanyl oleate.
Keywords: Whole aerial parts, Centella asiatica, Soxhlet, Column, Heptacosanyl oleate.
Kokate CK, Purohit AP, Gokhale SB. Textbook of Pharmacognosy. 49th ed. Pune: Nirali Prakashans; 2014. p. 954-5.
Available from: http://www.drugs.com/npp/gotu-kola.html.
The Wealth of India: A Dictionary of Raw materials and Industrial Products-Raw Material Series (Ca-Ci). Vol.3. New Delhi: Publications and Information Directorate, CSIR; 1992. p. 428-30.
Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants. 5th ed. New Delhi: Central Drug Research Institute, Lucknow and National Institute of Science Communication; 2005. p. 188-9.
Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants. 3rd ed. New Delhi: Central Drug Research Institute, Lucknow and National Institute of Science Communication; 2001. p. 159-60.
Suguna L, Sivakumar P, Chandrakasan G. Effects of Centella asiatica extract on dermal wound healing in rats. Indian J Exp Biol 1996;34(12):1208-11.
Shakir S. C. asiatica (linn.) Urban-A review. J Nat Prod Radia 2007;6(2):158-70.
Jamil SS, Nizami Q, Salam M. Centella asiatica (L) Urban - A review. Nat prod Radia, 2007;6(2):158-70.
Bhavana D, Jyoti, K. Centella asiatica: The elixir of life. Int J Res Aurveda Pharm 2011;2(2):431-8.
Cheng CL, Guo JS, Luk J, Koo MW. The healing effects of Centella extract and asiaticoside on acetic acid induced gaastric ulsers in rats. Life Sci 2004;74(18):2237-49.
Jayashree G, Kurup Muraleedhara G, Sudarslal S, Jacob VB. Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice. Fitoterapia 2003;74(5):431-4.
Evans WC, Trease GE. (2002). Pharmacognosy. 15th ed. New York, NY, USA: W.B. Saunders; 2002. p. 303-304.
Mukherjee PK. Quality Control of Herbal Drugs. 1st. ed. New Delhi: Business Horizon Pharmaceutical Publishers; 2002. p. 677.
Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C. Screening of Indian plants for biological activity: I. Indian J Exp Biol 1968;6(4):232-47.
Yoosook C, Bunyapraphatsara N, Boonyakiat Y, Kantasuk C. Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants. Phytomedicine 2000;6(6):411-9.
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