Sattanathan K, Chachu Kuriakose, Naseem Shifafiya M, Nelta S Tharakan, Sambath Kumar R


Objective: The objective of the work was to study the clinical profile of stroke in a tertiary care hospital.
Methods: A prospective observational study on stroke was carried out for a period of 6-month (May 2015 to October 2015). A total of 241 inpatients
from Shri Preethi Hospital were incorporated in the study. The data were collected and evaluated by reviewing case files and patient interview.
Result and Conclusion: Out of 241 patients, an incidence of ischemic stroke was found to be higher. The occurrence of stroke steeply rises with age
with male predominance. The burden of stroke tends to be more in rural, illiterate, and low socioeconomic status population. The study reveals risk
factors such as sedentary lifestyle, previous and family history of stroke, underlying disease like hypertension, diabetes. The circadian pattern in onset
showed a significant peak in morning (6 am-12 pm) for Ischemic and afternoon (12 pm-6 pm) for hemorrhagic stroke. Topographic distribution of
cerebral infract and hemorrhage was found to be in parietal lobe and periventricular white matter, respectively. Mostly prescribed medication for
ischemic and hemorrhagic patients was antihypertensive and mannitol, respectively. The contraindication for thrombolytic therapy was found to be
low economic status and average delay in time of presentation to hospital. The study highlights the need for aggressive management of traditional
risk factors, need for extensive work up in patient to find etiologies and need for more active interventions in community for the prevention of stroke.
Keywords: Ischemic, Hemorrhagic, Circadian pattern, Antihypertensive.

| PDF |


Stroke, World Heart Federation. The global burden of stroke. Available from: http://www.worldheart federation.org/cardiovascular-health stroke. [Last updated on 2015 Jan 02, Last assessed on 2015 Jul 01].

Thrift AG, Cadilhac DA, Thayabaranathan T, Howard G, Howard VJ, Rothwell PM, et al. Global stroke statistics. Int J Stroke 2014;9(1):6-18.

Pandian JD, Sudhan P. Stroke epidemiology and stroke care services in India. J Stroke 2013;15(3):128-34.

Anthony S, Kasper L, Dan L, Braunwald E. Harrison’s Principles of Internal Medicine. 17th ed. United States of America, NY: McGraw-Hill; 2012.

Gary D, Stephen J. Pathophysiology of Disease an introduction to Clinical Medicine. 7th ed. New York, NY: McGraw-Hill; 2014.

Glen C, Zhi L, Boryana S, Bradley P, Xinhua Z. Hemorrhagic transformation after ischemic stroke in animals and humans. J Cereb Blood Flow Metab 2014;34(2):185-99.

Subha PP, Pillai Geethakumari SM, Athira M, Nujum ZT. Pattern and risk factors of stroke in the young among stroke patients admitted in medical college hospital, Thiruvananthapuram. Ann Indian Acad Neurol 2015;18(1):20-3.

Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ, Demaerschalk BM, et al. Guidelines for the early management of patients with acute ischemic stroke: A guideline for healthcare professionals from the American heart association/American stroke association. Stroke 2013;44(3):870-947.

Marinigh R, Lip GY, Fiotti N, Giansante C, Lane DA. Age as a risk factor for stroke in atrial fibrillation patients: Implications for thromboprophylaxis. J Am Coll Cardiol 2010;56(11):827-37.

Haast RA, Gustafson DR, Kiliaan AJ. Sex differences in stroke. J Cereb Blood Flow Metab 2012;32(12):2100-7.

Lisabeth L, Bushnell C. Stroke risk in women: The role of menopause and hormone therapy. Lancet Neurol 2012;11(1):82-91.

James AH, Bushnell CD, Jamison MG, Myers ER. Incidence and risk factors for stroke in pregnancy and the puerperium. Obstet Gynecol 2005;106(3):509-16.

American stroke association. Understanding stroke risk. Available form: http://www.strokeassociation.org. [Last accessed on 2015 Jul 01].

Eriksson JG, Forsén T, Tuomilehto J, Osmond C, Barker DJ. Early growth, adult income, and risk of stroke. Stroke 2000;31(4):869-74.

Lee JH, Lee JY, Ahn SH, Jang MU, Oh MS, Kim CH, et al. Smoking is Not a Good Prognostic Factor following First-Ever Acute Ischemic Stroke. J Stroke 2015;17(2):177-91.

Leira EC, Hess DC, Torner JC, Adams HP Jr. Rural-urban differences in acute stroke management practices: A modifiable disparity. Arch Neurol 2008;65(7):887-91.

Koton S, Schneider AL, Rosamond WD, Shahar E, Sang Y, Gottesman RF, et al. Stroke incidence and mortality trends in US communities, 1987 to 2011. JAMA 2014;312(3):259-68.

Porcello Marrone LC, Farina Brunelli JP, Lutzky Saute R, Henrique Tomasi G, Cecchele Madeira B, Alves Martins W, et al. Cardioembolic sources in stroke patients in South of Brazil. Thrombosis 2014;2014:753780.

Zhao W, Katzmarzyk PT, Horswell R, Wang Y, Johnson J, Hu G. Sex differences in the risk of stroke and HbA(1c) among diabetic patients. Diabetologia 2014;57(5):918-26.

Eapen RP, Parikh JH, Patel NT. A study of clinical profile and risk factors of cerebrovascular stroke. Guj Med J 2009;64(2):47-54.

Øygarden H, Fromm A, Sand KM, Eide GE, Thomassen L, Naess H, et al. Stroke patients’ knowledge about cardiovascular family history-the Norwegian Stroke in the Young Study (NOR-SYS). BMC Neurol 2015;15:30.

Vasavilatha G, Krishna M, Kranthi P, Chandrasekar M. Study on role of risk factor cerebrovascular stroke. JEMDS 2015;4(6):914-24.

Kumar A, Prasad M, Kathuria P, Nair P, Pandit AK, Sahu JK, et al. Low socioeconomic status is an independent risk factor for ischemic stroke: A case-control study in North Indian population. Neuroepidemiology 2015;44(3):138-43.

Wang HJ, Si QJ, Shan ZL, Guo YT, Lin K, Zhao XN, et al. Effects of body mass index on risks for ischemic stroke, thromboembolism, and mortality in Chinese atrial fibrillation patients: A single-center experience. PLoS One 2015;10(4):e0123516.

Imano H, Kitamura A, Sato S, Kiyama M, Ohira T, Yamagishi K, et al. Trends for blood pressure and its contribution to stroke incidence in the middle-aged Japanese population: The Circulatory Risk in Communities Study (CIRCS). Stroke 2009;40(5):1571-7.

Khalid W. Clinical profile of stroke patients and the association of carotid intimamedia thickness at Al-Madinah, Saudi Arabia. Life Sci J 2015;12(3):1-6.

Indira Y, Muralidhar MV, Munisekhar K. Role of smoking and alcoholism in cerebrovascular Accidents. Int J Physiother Res 2014;2(3):530-6.

Mateen F, Carone M, Alam N, Streatfield K. A population based case control study of 1250 stroke death in rural Bangladesh. Eur J Neurol 2012;19(7):999-1006.

Boden-Albala B, Elkind MS, White H, Szumski A, Paik MC, Sacco RL. Dietary total fat intake and ischemic stroke risk: The Northern Manhattan Study. Neuroepidemiology 2009;32(4):296-301.

Lopez-Garcia E, Rodriguez-Artalejo F, Rexrode KM, Logroscino G, Hu FB, van Dam RM. Coffee consumption and risk of stroke in women. Circulation 2009;119(8):1116-23.

Larsson SC, Orsini N. Coffee consumption and risk of stroke: A dose-response meta-analysis of prospective studies. Am J Epidemiol 2011;174(9):993-1001.

Zhang R, Yan W, Song B, Hans S. Coffee consumption and risk of stroke: A meta-analysis of cohort studies. Cent Eur J Med 2012;7(3):310-6.

Dana MF, Daniel GN, Lacramioara PD. Circadian pattern of Ischemic stroke onset. HVM Bioflux 2014;6(3):132-9.

Geetha S, Sathisha A, Balaji V, Swetha ES. Analysis of drug utilization pattern among Hypertensive patients admitted to medical intensive care unit of a tertiary care hospital. WJPR 2015;4(3):1320-30.

White JR, Bettencourt-Silva JH, Potter JF, Loke YK, Myint PK. Changes in antiplatelet use prior to incident Ischaemic stroke over 7 years in a UK centre and the association with stroke subtype. Age Ageing 2013;42(5):594-8.

Preethi PB, Abdul N, Shreya S, Sri Lakshmi G. Prescribing pattern of drugs in stroke patients admitted to a multi-specialty hospital, India. IAJPR 2014;4(2):1015-20.

Joseph TD, Robert L, Gary C, Gary R. Pharmacotherapy a Pathophysiological Approach. 7th ed. New York, NY: McGraw-Hill; 2008. p. 373-83.

About this article







Additional Links

Manuscript Submission


Asian Journal of Pharmaceutical and Clinical Research
Vol 9 Suppl 3 December 2016 Page: 178-181

Print ISSN


Online ISSN


Authors & Affiliations

Sattanathan K
Department of Pharmacy Practice, J.K.K.Nattraja College of Pharmacy, Kumarapalayam- 638183, Tamil Nadu, India.

Chachu Kuriakose

Naseem Shifafiya M

Nelta S Tharakan

Sambath Kumar R

Article Tools

Email this article (Login required)
Email the author (Login required)


  • There are currently no refbacks.