Glycyrrhiza glabra is well known herb in Indian and Chinese traditional medicines.In our previous study it shows hair grwth promoting property in female rats so here experiments were performed for evaluating its effects in androgenic alopecia in males.


In present study alopecia is induced in three groups(each contain six animals) of male wistar albino rats by intramuscular dose(0.1mL) of testosterone .One group was rendered devoid of any other treatment while other two groups animals are  treated with finasteride and petroleum ether extract of G. glabra root  topically once daily. The animals were observed during treatment period of 21 days then one animal from each group was  euthanized for histoarchitecture  study.

Results and discussion

The study revealed that petroleum ether and finasteride treated animals do not developed alopecia while alopecia was observed in only testosterone treated animals.


Thus it is concluded from this study that petroleum ether extract of G. glabra posses  anti androgenic alopecia activity which is comparable to  that of standard drug finasteride.


Paus R, Costeralis CG.The biology of hair follicle. NewEngl J Med 1999 341: 493-497

Norwood O T.Male-pattern baldness. Classification and incidence. South Med. J. 1975; 68: 1359–1370.

ChopraRA, Nair SL,Chopra IC.Glossary of Ind Med. Plants.Council of scie ntific and industrial research New Delhi 1956:126.

Chatterjee A , Pakrashi S. The treatise of Indianmedicinal plants. National Institute of SciCommun, New Delhi 1992; pp 67-180.

Ministry of Environment and Forests, Government of India Public information: Good Practices:CPCSEA guidelines [Cited 2012 May 26].Available from: http://moef.nic.in

A.S.T.M. Standard Practice for testing biomaterials in rabbits for primary skin irritation, A.S.T.M. designation F719-81; Philadelphia: AmericanSociety for Testing of Materials 1998; pp 178–179.

Roy RK, Mayank T, Dixit VK 2008. Hair growth promoting activity of Eclipta alba in male albino rats. ArchDermatol Res 300: 357-364.

Matias JR, Malloy V, Orentreich N 1989. Animal models of androgen-dependent disorders of the pilosebaceous apparatus. 1. The androchronogenetic alopecia (AGA)

mouse as a model for male-pattern baldness. Arch Dermatol Res 281: 247-253.

Parthasarathy S, Malloy V, Matias J, Massardo S, Bariether L,Kotes J, Orentreich N. The in-vitro transformationof testosterone and the ability of its 5α-reduced 17 beta hydroxylated metabolites, to induce hair loss in the androchronogenetic alopecia (AGA) mouse (abstract). JInvest Dermatol 1992:98: 4.

Hamilton JB 1942. Male hormone stimulation is a prerequisite and an incitant in common baldness. Am J Anat 1942:71: 451-480.

UpadhyayS, Ghosh A K and Singh V. Hair Growth Promotant Activity of Petroleum Ether Root Extract of Glycyrrhiza Glabra L (Fabaceae) in Female Rats Trop J Pharm Res, October 2012;11 (5): 753-58

Josephs RA, Guinn JS, Harper LM, Askari F.Liquorice consumption and salivary testosterone concentrations. Lancet 2001;358: 1613–1614.

Yaginuma T, Izumi R, Yasui H, Arai T, Kawabata M.Effect of traditional herbal medicine on serumtestosterone levels and its induction of regular ovulation in hyperandrogenic and oligomenorrheic women (Article in Japanese).Nippon Sanka Fujinka Gakkai Zasshi 1982;34(7): 939-944.

Spires TE, Fink BE, Kick EK, You D, Rizzo CA, Takenaka I, Lawrence

RM, Ruan Z, Salvati ME, Vite GD, Weinmann R, Attar RM, Gottardis MM, Lorenzi MV.Prostate..Identification of novel functional inhibitors of 17beta-hydroxysteroid

dehydrogenase type III (17beta-HSD3). 2005 Oct 1;65(2):159-70.



How to Cite

SUKIRTI, U., and S. VIJENDER. “POTENTIALITY OF PETROLEUM ETHER (60-80) °C EXTRACT OF GLYCYRRHIZA GLABRA ON ANDROGENIC ALOPECIA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 6, no. 7, Aug. 2013, pp. 52-55, https://innovareacademics.in/journals/index.php/ajpcr/article/view/138.