ANTIOXIDANT PROPERTY OF ANTIHYPERTENSIVE DRUGS (CARVEDILOL, ENALAPRIL, AND AMLODIPINE) ON LIVER FUNCTION IN ANIMAL (RATS) MODELS
Objective: The antihypertensive drugs (beta-blockers - carvedilol, calcium channel blocker - amlodipine, and angiotensin-converting enzyme
inhibitor - enalapril) were investigated for its hepatoprotective effect by antioxidant property against carbon tetrachloride (CCl
)-induced acute liver
damage on albino rats.
Methods: In this study the liver was damaged by giving Carbon tetra chloride (CCl
)-1 ml/kg-p.o. After giving CCl
(1 ml/kg), it significantly elevated
the serum levels of biochemical markers such as serum glutamate-pyruvate transaminase, serum glutamic oxaloacetic transaminase, alkaline
phosphatase, total bilirubin, protein, and depleted antioxidant enzymes glutathione. After treatment with carvedilol (10 mg/kg), enalapril (0.5 mg/kg),
and amlodipine (10 mg/kg) for 2 weeks, these drugs were significantly reduces the elevated levels of biochemical markers mentioned above.
Conclusion: These results suggest that these antihypertensive drugs may have the potential therapeutic value in the treatment of CCl
hepatic damage and some liver diseases. Hepatoprotective activity of these drugs may be attributed to the antioxidant principles in it.
Keywords: Antioxidant, Carvedilol, Enalapril, Amlodipine, Carbon tetrachloride, Hepatoprotective.
1. Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal
ions in human disease: An overview. Methods Enzymol 1990;186:1-85.
2. Rimbach G, Fuchs J, Packer L. Application of nutrigenomics tools to
analyze the role of oxidants and antioxidants in gene expression. In:
Rimbach G, Fuchs J, Packer L, editors. Nutrigenomics. FL, USA:
Taylor and Francis Boca Raton Publishers; 2005. p. 1-12.
3. KÃ¤hkÃ¶nen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Kujala TS,
et al. Antioxidant activity of plant extracts containing phenolic
compounds. J Agric Food Chem 1999;47:3954-62.
4. Vaidyaratnam PS. Varierâ€™s Indian Medicinal Plants (Compendium of
500 Species). Vol. 5. Hyderabad: Orient Longman; 1997.
5. Semiz A. Antioxidant effect of beta blockers in preclinical studies. Afr
J Biotechnol 2007;6(3):273-7.
6. Health Effects Test Guidelines, Acute Oral Toxicity (Computer
Program). OPPTS 870, 1100 United States Office of prevention,
Pesticides and Toxic Substances Environmental Protection Agency.
(7101). Available from: http://www.epa.gov/opptsfrs/home/guideline.
7. Sahu N, Das S. Hepatoprotective activity of Eugenia jumbose Linn. On
albino rats. IJP 2006;5:22-6.
8. Galighor AE, Kozloff EN. Essentials of Practical Micro Technique.
ed. New York: Lea and Fibiger; 1976.
9. Jitendra J, Vineeta T, Ashok K, Brijesh K, Singh P. Rosa centifolia:
Plant review. Int J Res Pharm Chem 2012;2(3):794-6.
10. Shenoy KA, Somayaji SN, Bairy KL. Hepatoprotective effect of
Ginkgo biloba in carbon tetrachloride induced hepatic injury in rats. IJP
11. Claret SB. Carvedilol effect on serum enzymes. Med J Can
12. Sallie R, Tredger JM, William R. Drugs and the liver. Part-1: Testing
liver functions. Biopharm Drug Dispos 1991;12(4):251-9.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.