A REVIEW ON â€œNEW TREATMENT STRATEGIES FOR ALZHEIMERâ€™S DISEASE AS NEURODEGENERATIVE DISEASE AND ITS RISK FACTOR CAUSE, SYMPTOMS, AND TREATMENT AT WORLDWIDEâ€
Alzheimerâ€™s disease (AD) is a dynamic and irreversible neurodegenerative illness and relates to the most widely recognized reason for dementia
around the world. AD is a dynamic and lethal cerebrum ailment. Alzheimerâ€™s obliterates mind cells, bringing on memory issue or misfortune and issues
with speculation and conduct sufficiently serious to influence work, long lasting leisure activities or social life. Alzheimerâ€™s illness is quickly becoming
worldwide, but there is no cure for it. Now, accessible medications just give symptomatic help and do not mediate in infection prepare adequately
enough to avert or cure it. Various late studies have reported that working memory does not appear to demonstrate regular age-related deficiencies
in solid more established grown-ups when enthusiastic data are included. Indeed, contingent upon the capacity included, patients might demonstrate
an enthusiastic advantage in their working memory execution. Moreover, this advantage is not generally obviously one-sided (e.g., toward negative
or positive data). We decipher this intricate example of results as an outcome of the cooperation between numerous components including the
seriousness of AD, the nature of emotional jolts, and sort of working memory errand. Clinical advantages of the accessible pharmacological treatment
for AD with antidementia drugs (to be specific cholinesterase inhibitors and Memantine) are obvious. In an unexpected way, learns about the transient
capacity to encode and effectively control enthusiastic data in dementia of Alzheimerâ€™s sort are few and have yielded blended results.
Keywords: Alzheimerâ€™s disease, Risk factor for Alzheimerâ€™s disease, Diagnosis, Classification of Anti-Alzheimerâ€™s drug.
2. Baddeley A. Working memory: Theories, models, and controversies. Annu Rev Psychol 2012;63:1-29.
3. Mikels JA, Reuter-Lorenz PA, Beyer JA, Fredrickson BL. Emotion and working memory: Evidence for domain-specific processes for affective maintenance. Emotion 2008;8(2):256-66.
4. Schmeichel BJ, Volokhov RN, Demaree HA. Working memory capacity and the self-regulation of emotional expression and experience. J Pers Soc Psychol 2008;5(6):1526-40.
5. Mammarella N, Borella B, Carretti B, Leonardi G, Fairfield B. Examining an emotion enhancement effect in working memory: Evidence from age-related differences. Neuropsychol Rehabil 2013;23(3):416-28.
6. Mikels JA, Larkin GR, Reuter-Lorenz PA, Carstensen LL. Divergent trajectories in the aging mind: Changes in working memory for affective versus visual information with age. Psychol Aging 2005;20(4):542-53.
7. Mather M. Aging and emotional memory. In: Reisberg D, Hertel P, editors. Memory and Emotion. NY: Oxford University Press; 2004. p. 272-307.
8. Gazzaley A, Sheridan MA, Cooney JW, Dâ€™Esposito M. Age-related deficits in component processes of working memory. Neuropsychology 2007;21(5):532-9.
9. Schultz RR, de Castro CC, Bertolucci PH. Memory with emotional content, brain amygdala and Alzheimerâ€™s disease. Acta Neurol Scand 2009;120(2):101-10.
10. Satler C, Tomaz C. Emotional working memory in Alzheimerâ€™s disease patients. Dement Geriatr Cogn Dis Extra 2011;1(1):124-38.
11. Dohnel K, Sommer M, Ibach B, Rothmayr C, Meinhardt J, Hajak G. Neural correlates of emotional working memory in patients with mild cognitive impairment. Neuropsychologia 2008;46(1):37-48.
12. Fleming K, Kim SH, Doo M, Maguire G, Potkin SG. Memory for emotional stimuli in patients with Alzheimerâ€™s disease. Am J Alzheimers Dis Other Demen 2003;18(6):340-2.
13. Boller F, El Massioui F, Devouche E, Traykov L, Pomati S, Starkstein SE. Processing emotional information in Alzheimerâ€™s disease: Effects on memory performance and neurophysiological correlates. Dement Geriatr Cogn Disord 2002;14(2):104-12.
14. Huijbers MJ, Bergmann HC, Rikkert MG, Kessels RP. Memory for emotional pictures in patients with Alzheimerâ€™s dementia: Comparing picture-location binding and subsequent recognition. J Aging Res 2001;2011:9.
15. Borg C, Leroy N, Favre E, Laurent B, Thomas-Anterion C. How emotional pictures influence visuospatial binding in short-term memory in ageing and Alzheimerâ€™s disease? Brain Cogn 2011;76(1):20-5.
16. Nashiro K, Mather M. Effects of emotional arousal on memory binding in normal aging and Alzheimerâ€™s disease. Am J Psychol 2011;124(3):301-12.
17. Daneman M, Carpenter PA. Individual differences in working memory and reading. J Verbal Learning Verbal Behav 1980;19(4):450-66.
18. Engle RW, Kane MJ. Executive attention, working memory capacity, and a two factor theory of cognitive control. In: Ross BH, editor. The Psychology of Learning and Motivation. Vol. 44. San Diego: Academic Press; 2006. p. 145-99.
19. Mammarella N, Fairfield B, De Leonardis V, Carretti B, Borella E, Frisullo E, et al. Is there an affective working memory deficit in patients with chronic schizophrenia? Schizophr Res 2012;138(1):99-101.
20. Turner ML, Engle RW. Is working memory capacity task dependent? J Mem Lang 1989;28(2):127-54.
21. Doninger NA, Bylsma FW. Inhibitory control and affective valence processing in dementia of the Alzheimer type. J Neuropsychol 2007;1:65-83.
22. Mather M, Knight M. Goal-directed memory: The role of cognitive control in older adultsâ€™ emotional memory. Psychol Aging 2005;20(4):554-70.
23. Kensinger EA, Corkin S. Effect of negative emotional content on working memory and long-termmemory. Emotion 2003;3(4):378-93.
24. Henry JD, Rendell PG, Scicluna A, Jackson M, Phillips LH. Emotion experience, expression, and regulation in Alzheimerâ€™s disease. Psychol Aging 2009;24(1):252-7.
25. Goodkind MS, Gyurak A, McCarthy M, Miller BL, Levenson RW. Emotion regulation deficits in frontotemporal lobar degeneration and Alzheimerâ€™s disease. Psychol Aging 2010;25(1):30-7.
26. Winecoff A, Labar KS, Madden DJ, Cabeza R, Huettel SA. Cognitive and neural contributors to emotion regulation in aging. Soc Cogn Affect Neurosci 2011;6(2):165-76.
27. LaBar KS, Cabeza R. Cognitive neuroscience of emotional memory. Nat Rev Neurosci 2006;7(1):54-64.
28. Watanabe M, Hikosaka K, Sakagami M, Shirakawa S. Reward expectancy-related prefrontal neuronal activities: Are they neural substrates of â€œaffectiveâ€ working memory? Cortex 2007;43(1):53-64.
29. Dâ€™Esposito M, Postle BR, Rypma B. Prefrontal cortical contributions to working memory: Evidence from event-related fMRI studies. Exp Brain Res;133(1):3-11.
30. Mather M, Canli T, English T, Whitfield S, Wais P, Ochsner K, et al. Amygdala responses to emotionally valenced stimuli in older and younger adults. Psychol Sci 2004;15(4):259-63.
31. Kensinger EA, Schacter DL. Neural processes supporting young and older adultsâ€™ emotional memories. J Cogn Neurosci 2008;20(7):1161-73.
32. Klein-Koerkamp Y, Baciu M, Hot P. Preserved and impaired emotional memory in Alzheimerâ€™s disease. Front Psychol 2012;3:331.
33. HorÃnek D, VarjassyovÃ¡ A, Hort J. Magnetic resonance analysis of amygdalar volume in Alzheimerâ€™s disease. Curr Opin Psychiatry 2007;20(33):273-7.
34. Poulin SP, Dautoff R, Morris JC, Barrett LF, Dickerson BC. Amygdala atrophy is prominent in early Alzheimerâ€™s disease and relates to symptom severity. Psychiatry Res Neuroimag 2011;194(1):7-13.
35. Perrin M, Henaff MA, Padovan C, Faillenot I, Merville A, Krolak-Salmon P. Influence of emotional content and context on memory in mild Alzheimerâ€™s disease. J Alzheimers Dis 2012;29:817-26.
Rosenbaum RS, Furey ML, Horwitz B, Grady CL. Altered connectivity among emotion-related brain regions during short-term memory inAlzheimerâ€™s disease. Neurobiol36. Aging 2010;31(5):780-6.
37. Mammarella N, Fairfield B, De Beni R, Cornoldi C. Aging and intrusion errors in an active visuo-spatial working memory task. Aging Clin Exp Res 2009;21(4-5):282-91.
38. Allen RJ, Baddeley AD, Hitch GJ. Is the binding of visual features in working memory resource-demanding? J Exp Psychol Gen 2006;135:298-313.
39. Kensinger EA, Anderson A, Growdon JH, Corkin S. Effects of Alzheimer disease on memory for verbal emotional information. Neuropsychologia 2004;42(6):791-800.
40. Forsteimer S, Maercker A, Maier W, van den Bussche H, Riedel-Heller S, Riedel-Heller S, et al. Motivational reserve: Motivation-related occupational abilities and risk of mild cognitive impairment and Alzheimer disease. Psychol Aging 2012;27(2):353-63.