ENTERIC FEVER IN TRAVELERS: AN UPDATED INSIGHT
Enteric fever is a broad term used to represent typhoid and paratyphoid fever which is caused by S. typhi and S. paratyphi respectively. The most
common cause being S. typhi, overall. However, S. paratyphi is known to infect the travelers at a higher rate. Indian subcontinent being one of the most
endemic region, it is always beneficial for the travelers to get immunized while traveling to these areas. However, Vaccination to S. paratyphi is not yet
available, hence travelers often fall prey to the disease. The morbidity is often high but mortality is very rare, especially due to first line treatment drugs
like ceftriaxone, nalidixic acid and floroquinolones (if patients are sensitive to it). Recently, it was observed that Multi-drug resistance (Resistance to at
least ampicillin, chloramphenicol and trimethoprim-sulfamethoxazole]) was limited to Typhi isolates and was increased at an exponential rate. Hence,
with increasing resistance to these drugs, developing vaccines or new drugs against these bacteria, remains an area of prime interest.
Keywords: Salmonella typhi, Salmonella paratyphi, Enteric fever, Traveler.
Vollaard AM, Ali S, van Asten HA, Widjaja S, Visser LG, Surjadi C, et al. Risk factors for typhoid and paratyphoid fever in Jakarta, Indonesia. JAMA 2004;291(21):2607-15.
Schwartz E, Shlim DR, Eaton M, Jenks N, Houston R. The effect of oral and parenteral typhoid vaccination on the rate of infection with Salmonella typhi and Salmonella paratyphi A among foreigners in Nepal. Arch Intern Med 1990;150(2):349-51.
Parry CM, Hien TT, Dougan G, White NJ, Farrar JJ. Typhoid fever. N Engl J Med 2002;347(22):1770-82.
Raffatellu M, Chessa D, Wilson RP, TÃ¼kel C, AkÃ§elik M, BÃ¤umler AJ. Capsule-mediated immune evasion: A new hypothesis explaining aspects of typhoid fever pathogenesis. Infect Immun 2006;74(1):19-27.
de Jong HK, Parry CM, van der Poll T, Wiersinga WJ. Host-pathogen interaction in invasive Salmonellosis. PLoS Pathog 2012;8(10):e1002933.
Ramsden AE, Mota LJ, MÃ¼nter S, Shorte SL, Holden DW. The SPI-2 type III secretion system restricts motility of Salmonella-containing vacuoles. Cell Microbiol 2007;9(10):2517-29.
Christie AB. Infectious Diseases: Epidemiology and Clinical Practice. 4th ed. Edinburgh, Scotland: Churchill Livingstone; 1987.
Buckle GC, Walker CL, Black RE. Typhoid fever and paratyphoid fever: Systematic review to estimate global morbidity and mortality for 2010. Journal of global health. 2012;2(1):10401.
Mortality GBD, Causes of Death C. Global, regional, and national ageâ€“sex specific all-cause and causespecific mortality for 240 causes of death, 1990â€“2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet.385(9963):117-71.
Steffen R, Rickenbach M, Wilhelm U, Helminger A, SchÃ¤r M. Health problems after travel to developing countries. J Infect Dis 1987;156(1):84-91.
Steinberg EB, Bishop R, Haber P, Dempsey AF, Hoekstra RM, Nelson JM, et al. Typhoid fever in travellers: Who should be targeted for prevention? Clin Infect Dis 2004;39(2):186-91.
Mermin JH, Townes JM, Gerber M, Dolan N, Mintz ED, Tauxe RV. Typhoid fever in the United States, 1985-1994: Changing risks of international travel and increasing antimicrobial resistance. Arch Intern Med 1998;158(6):633-8.
Ryan CA, Hargrett-Bean NT, Blake PA. Salmonella typhi infections in the United States, 1975-1984: Increasing role of foreign travel. Rev Infect Dis 1989;11:1-8.
Behrens R, Carroll B. The 10-Year trend of travel-associated infections imported into the UK. 7th Conference of the International Society of Travel Medicine; Innsbruck, Austria; May 27-31; 2001.
GBD 2013 Mortality and Causes of Death, Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015;385(9963):117-71.
Gupta SK, Medalla F, Omondi MW, et al. Laboratory-based surveillance of paratyphoid fever in the United States: Travel and antimicrobial resistance. Clinical infectious diseases: An official publication of the Infectious Diseases Society of America. 2008;46(11):1656-63.
Ackers ML, Puhr ND, Tauxe RV, Mintz ED. Laboratory-based surveillance of Salmonella serotype Typhi infections in the United States: antimicrobial resistance on the rise. JAMA : the journal of the American Medical Association. 2000;283(20):2668-73.
Lynch MF, Blanton EM, Bulens S, et al. Typhoid fever in the United States, 1999-2006. JAMA: The journal of the American Medical Association. 2009;302(8):859-65.
Reddy S, Rangaiah J, Addiman S, Wareham D, Wilson P, Sefton A. Epidemiology, antibiotic resistance trends and the cost of enteric fever in East London, 2005-2010. Travel medicine and infectious disease. 2011;9(4):206-12.
Ty AU, Ang GY, Ang LW, James L, Goh KT. Changing epidemiology of enteric fevers in Singapore. Annals of the Academy of Medicine, Singapore. 2010;39(12):889-88.
Clark TW, Daneshvar C, Pareek M, Perera N, Stephenson I. Enteric fever in a UK regional infectious diseases unit: A 10 year retrospective review. The Journal of infection. 2010;60(2):91-98.
Keller A, Frey M, Schmid H, Steffen R, Walker T, Schlagenhauf P. Imported typhoid fever in Switzerland, 1993 to 2004. Journal of travel medicine. 2008;15(4):248-251.
Date KA, Newton AE, Medalla F, Blackstock A, Richardson L, McCullough A, Mahon, BE. (2016). Changing Patterns in Enteric Fever Incidence and Increasing Antibiotic Resistance of Enteric Fever Isolates in the United States, 2008â€“2012. Clinical Infectious Diseases, ciw232.
Oâ€™Brien D, Tobin S, Brown GV, Torresi J. Fever in returned travelers: Review of hospital admissions for a 3-year period. Clin Infect Dis 2001;33(5):603-9.
Jelinek T, Nothdurft HD, von Sonnenburg F, LÃ¶scher T. Risk factors for typhoid fever in travelers. J Travel Med 1996;3:200-203.
Cammie FL, Miller SL. Salmonellosis. In: Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, editors. Harrisonâ€™s Principles of Internal Medicine. New York: McGraw-Hill, 2005. p. 897-900.
Bhutta ZA, Mansurali N. Rapid serologic diagnosis of pediatric typhoid fever in an endemic area: A prospective comparative evaluation of two dot-enzyme immunoassays and the widal test. Am J Trop Med Hyg 1999;61:654-7.
Ali AM, Gandhi V, Malla S. (2014). Development of multiplex pcr based assay for the concurrent detection of pathogenic microorganisms. International Journal of Current Pharmaceutical Research, 6(4), 25-27.
Rabie Zahran. Typhoid Fever. Available from: http://www.slideshare.net/rabiezahran/typhoid-fever-3610355. [Accessed on 2016 Aug, 31].
Hamer DH, Connor BA. Travel health knowledge, attitudes and practices among United States travelers. Journal of travel medicine. 2004;11(1):23-26.
Whitaker JA, Franco-Paredes C, del Rio C, Edupuganti S. Rethinking typhoid fever vaccines: Implications for travelers and people living in highly endemic areas. J Travel Med 2009;16(1):46-52.
Mirza SH, Beeching NJ, Hart CA. Multi-drug resistant typhoid: A global problem. J Med Microbiol 1996;44(5):317-9.
Gupta A. Multidrug-resistant typhoid fever in children: Epidemiology and therapeutic approach. Pediatr Infect Dis J 1994;13(2):134-40.
Mermin JH, Villar R, Carpenter J, Roberts L, Samaridden A, Gasanova L, et al. A massive epidemic of multidrug-resistant typhoid fever in Tajikistan associated with consumption of municipal water. J Infect Dis 1999;179(6):1416-22.
Alam MN, Haq SA, Das KK, Baral PK, Mazid MN, Siddique RU, et al. Efficacy of ciprofloxacin in enteric fever: Comparison of treatment duration in sensitive and multidrug-resistant Salmonella. Am J Trop Med Hyg 1995;53(3):306-11.
Frenck RW Jr, Nakhla I, Sultan Y, Bassily SB, Girgis YF, David J, et al. Azithromycin versus ceftriaxone for the treatment of uncomplicated typhoid fever in children. Clin Infect Dis 2000;31(5):1134-8.
Effa EE, Bukirwa H. Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever). Cochrane Database Syst Rev 2008;CD006083.
Nath G, Maurya P. Drug resistance patterns in Salmonella enterica subspecies enterica serotype typhi strains isolated over a period of two decades, with special reference to ciprofloxacin and ceftriaxone. Int J Antimicrob Agents 2010;35(5):482-5.
Stubi CL, Landry PR, PÃ©tignat C, Bille J, Genton B, Darioli R, et al. Compliance to live oral Ty21a typhoid vaccine, and its effect on viability. J Travel Med 2000;7(3):133-7.
Eff ARY, Rahayu ST. (2016). The antibacterial effects of essential oil from galangal rhizome alpinia galanga (Linn.) Pierre ON RAT (Rattus norvegicus L.) were infected by Salmonella typhi. Asian Journal of Pharmaceutical and Clinical Research, 189-193.
Krishna, G., Kumar, S., Pranitha, V., Alha, M., & Charaya, S. (2015). Biogenic synthesis of silver nanoparticles and their synergistic effect with antibiotics: A study against salmonella SP. International journal of pharmacy and pharmaceutical Sciences, 7(11), 84-88. Retrieved from http://innovareacademics.in/journals/index.php/ijpps/article/view/7594.
Kanta Kanthal L, Dey A, Satyavathi K, Bhojaraju, P. (2014). Antibacterial potential of methanolic extract of gyrocarpus asiaticus willd. Asian Journal of Pharmaceutical and Clinical Research, 7(1), 192-194.
Mehta J, Jandaik SU. (2016). Evaluation of Phytochemicals and synergistic interaction between plant extracts and antibiotics for efflux pump inhibitory activity against salmonella typhimurium strains. International Journal of Pharmacy and Pharmaceutical Sciences, 8(10). Retrieved fromhttp://innovareacademics.in/journals/index.php/ijpps/article/view/14062.
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