FORMULATION AND EVALUATION OF PERINDOPRIL MICROENCAPSULES BY USING DIFFERENT POLYMER

  • Leena Jacob
  • Abhilash Tv
  • Shajan Abraham

Abstract

Objective: The study was carried out with an objective to achieve a potential sustained release oral drug delivery system of an antihypertensive drug, Perindopril which is a ACE inhibitor having half life of 2 hours. Perindopril is water soluble drug, so we can control or delay the release rate of drug by using release retarding polymers. This may also decrease the toxic side effects by preventing the high initial concentration in the blood.

Method: Microcapsules were prepared by solvent evaporation technique using Eudragit L100 and Ethyl cellulose as a retarding agent to control the release rate and magnesium stearate as an inert dispersing carrier to decrease the interfacial tension between lipophilic and hydrophilic phase.

 Results: Prepared microcapsules were evaluated for the particle size, percentage yield, drug entrapment efficiency, flow property and in vitro drug release for 12 h. Results indicated that the percentage yield, mean particle size, drug entrapment efficiency and the micrometric properties of the microcapsules was influenced by various drug: polymer ratio. The release rate of microcapsules could be controlled as desired by adjusting the combination ratio of dispersing agents to retarding agents.

Conclusion:Perindopril microcapsules can be successfully designed to develop sustained drug delivery, that reduces the dosing frequency and their by one can increase the patient compliance.

References

1. Jain NK. Controlled and Novel Drug Delivery. 5th ed. New Delhi: CBS Publishers and Distributers; 2002. p. 237-51.
2. Venkatesan P, Manavalan R, Valliappan K. Microencapsulation: A vital technique in novel drug delivery system. J Pharm Sci Res 2009;1(4):26-35.
3. Hoffman A, Stepensky D, Lavy E, Eyal S, Klausner E, Friedman M.
Pharmacokinetic and pharmacodynamic aspects of gastroretentive dosage forms. Int J Pharm 2004;277(1-2):141-53.
4. Brahmankar DM, Jaiswal SB. 4. Atriatse. Biopharmaceutics and
Pharmacokinetics. 3rd ed. New Delhi: Vallabh Prakashan; 2000. p. 335-71.
5. Ma N, Xu L, Wang Q, Zhang X, Zhang W, Li Y, et al. Development and evaluation of new sustained-release floating microspheres. Int J Pharm
2008;358(1-2):82-90.
6. Pharma Professional Services; 2010. Available from: http://www.drug. infosys.com/Drug.aspx/drugCode961/perindoprilerbbu mine 24/3/10. [Last cited on 2012 Jun 28].
7. Wikimedia Foundation; 2013. Available from: http://www.en.wikipedia. org/wiki/Perindopril. [Last cited on 2013 Feb 27].
8. Horoz BB, Kiliic M, Arslan N, Baykara YT. Effect of different dispersing agents on the characteristics of Eudragit microspheres prepared by a solvent evaporation method. J Microencapsul 2004;21(2):191-202.
9. Saravanan M, Dhanaraju MD, Sridhar SK, Ramachandran S, Sam SK, Anand P, et al. Preparation, characterization and in vitro release kinetics of ibuprofen polystyrene microspheres. Indian J Pharm Sci
2004;66(3):287-92.
10. Patel A, Ray S, Thakur RS. In vitro evaluation and optimization of controlled release floating drug delivery system of metformin hydrochloride. DARU 2006;14(2):57-64.
11. Lachman L, Partic D. Kinetic principles and stability. Theory and Practice of Industrial Pharmacy. 3rd ed. Philadelphia, PA: Varghese Publishing House; 1987. p. 767.
12. Kulkarni GT, Gowthamarajan K, Suresh B. Stability testing of pharmaceutical products: An overview. Indian J Pharm Educ
2004;38(4):194-202.
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How to Cite
Jacob, L., A. Tv, and S. Abraham. “FORMULATION AND EVALUATION OF PERINDOPRIL MICROENCAPSULES BY USING DIFFERENT POLYMER”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 2, Feb. 2017, pp. 153-6, doi:10.22159/ajpcr.2017.v10i2.14899.
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Original Article(s)