THE ANTIDEPRESSANT DRUG DOXEPIN: A PROMISING ANTIOXIDANT


Shauroseni Palchoudhuri, Debanjan Mukhopadhyay, Debalina Sinha Roy, Bidisha Ghosh, Sukhen Das, Sujata G. Dastidar

Abstract


ABSTRACT
Objective: Oxidative stress contributes to the pathophysiology of exposure to environmental pollutants and to different free radical generating
biochemical reactions in a human system leading to various types of age-related ailments. An antioxidant is a substance capable of preventing
or slowing down oxidation of other molecules. Administration of different natural or synthetic antioxidants can ably lead to prevention and
attenuation of such stress-induced biochemical alterations. Best examples of natural antioxidants are plant-derived flavonoids. The present
study has been designated to determine antioxidant properties in antidepressant compound doxepin which is structurally similar to flavonoid
quercetin.
Methods: Antioxidant capacity in doxepin was determined with help of several standard conventional procedures such as phosphomolybdenum
assay, Ferric ion and cupric ion reducing power assays, ferrous ion chelating activity assay, hydrogen peroxide, and nitric oxide scavenging activity
assays.
Results: Doxepin showed a stable rise in its antioxidant activity in a dose-dependent manner as determined by ferric as well as cupric ion reducing
capacity and by phosphomolybdenum assay. An almost identical observation was noted while determining ferrous ion chelating activity. Furthermore,
doxepin showed a strong nitric oxide scavenging activity in all the concentrations used in the study while its hydrogen peroxide scavenging activity
was only observed at 500 μg/ml of doxepin.
Conclusion: Thus, our study opens up a new vista in search for antioxidants not only from plant sources but also from clinically established
pharmaceutical compounds that are already in practical use among patients.
Keywords: Antioxidant, Antidepressant, Doxepin, Quercetin, Flavanol, Flavonoids.


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About this article

Title

THE ANTIDEPRESSANT DRUG DOXEPIN: A PROMISING ANTIOXIDANT

DOI

10.22159/ajpcr.2017.v10i3.15149

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 97-102

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

199 Views | 204 Downloads

Authors & Affiliations

Shauroseni Palchoudhuri
Department of Microbiology, Herbicure Healthcare Bio-Herbal Research Foundation, Kolkata 700154
India

Debanjan Mukhopadhyay
School of Veterinary Medicine, Department of Pathology, Microbiology and Immunology , University of California, Davis, CA
United States

Debalina Sinha Roy
Department of Microbiology, Herbicure Healthcare Bio-Herbal Research Foundation, Kolkata 700154
India

Bidisha Ghosh
Division of Biophysics, Department of Physics, Jadavpur University, Kolkata 700032
India

Sukhen Das
Division of Biophysics, Department of Physics, Jadavpur University, Kolkata 700032
India

Sujata G. Dastidar
Research Director, Herbicure Healthcare Bio-Herbal Research Foundation, Kolkata 700154, India
India


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