THE ANTIDEPRESSANT DRUG DOXEPIN: A PROMISING ANTIOXIDANT
Objective: Oxidative stress contributes to the pathophysiology of exposure to environmental pollutants and to different free radical generating
biochemical reactions in a human system leading to various types of age-related ailments. An antioxidant is a substance capable of preventing
or slowing down oxidation of other molecules. Administration of different natural or synthetic antioxidants can ably lead to prevention and
attenuation of such stress-induced biochemical alterations. Best examples of natural antioxidants are plant-derived flavonoids. The present
study has been designated to determine antioxidant properties in antidepressant compound doxepin which is structurally similar to flavonoid
Methods: Antioxidant capacity in doxepin was determined with help of several standard conventional procedures such as phosphomolybdenum
assay, Ferric ion and cupric ion reducing power assays, ferrous ion chelating activity assay, hydrogen peroxide, and nitric oxide scavenging activity
Results: Doxepin showed a stable rise in its antioxidant activity in a dose-dependent manner as determined by ferric as well as cupric ion reducing
capacity and by phosphomolybdenum assay. An almost identical observation was noted while determining ferrous ion chelating activity. Furthermore,
doxepin showed a strong nitric oxide scavenging activity in all the concentrations used in the study while its hydrogen peroxide scavenging activity
was only observed at 500 Î¼g/ml of doxepin.
Conclusion: Thus, our study opens up a new vista in search for antioxidants not only from plant sources but also from clinically established
pharmaceutical compounds that are already in practical use among patients.
Keywords: Antioxidant, Antidepressant, Doxepin, Quercetin, Flavanol, Flavonoids.
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