A STUDY OF MULTIORGAN DYSFUNCTION IN PATIENTS WITH DENGUE AND ITS CLINICO- HAEMATOLOGICAL CORRELATION WITH SEVERITY.


Jadumani Nayak, Sudeshna Behera, Shrikanta Kumar Swain, Smaraka Ranjan Panda

Abstract


Objective: To study of multiorgan dysfunction in patients with dengue and to correlate the severity and clinical outcome with different haematological parameters.

Material & methods: All suspected cases of dengue admitted to Medicine dept within 1 year period were evaluated & classified as DF(dengue fever), DHF(dengue hemorrhagic fever), DSS(dengue shock syndrome).

Results: out of total 150 cases,108 cases were classified as DF, 31 cases as DHF and 11 cases as DSS. Liver involvement was seen in 97.33% cases. Jaundice was observed in 10 cases(6.6%),abnormal AST(aspartate transaminase) in 146 (97.33 %) cases and abnormal ALT(alanine transaminase)in 126 (84%) cases. Bleeding manifestations was reported in 61 patients (40.6%).Presence of GI Bleeding in 17 patients (11.3%) was related to severe disease. Thrombocytopenia was present in 25% of DF cases, and in all cases of DHF and DS. Among these, PT(prothrombin time) was prolonged in 10 cases and aPTT(activated partial thromboplastin time) in 47 patients. Serum Fibrinogen was low in 28.57 % of patients. Multiorgan dysfunction was observed in the form of simultaneous hepatic and renal dysfunction in 3.33 % of cases, hepatic and CNS dysfunction in 2.66% of cases, hepatic & cardiac dysfunction in 2% of cases and all the organ system dysfunction in 0.67% of cases.

Conclusion: The extent of rise of liver enzymes, PT, aPTT & fall of serum fibrinogen, and degree of thrombocytopenia correlated with disease severity. Acute renal failure, encephalitis and myocarditis are manifestations of severe form of dengue. Major organ involvement may occur in simple DF also.


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About this article

Title

A STUDY OF MULTIORGAN DYSFUNCTION IN PATIENTS WITH DENGUE AND ITS CLINICO- HAEMATOLOGICAL CORRELATION WITH SEVERITY.

DOI

10.22159/ajpcr.2017.v10i2.15332

Date

01-02-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 2 February 2017 Page: 218-221

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Jadumani Nayak
Associate Professor Department of Medicine S.C.B. Medical College, Cuttack Odisha
India

Sudeshna Behera
Assistant professor Department of Biochemistry, IMS & SUM Hospital, Siksha ‘O’ Anusandhan University Bhubaneswar,Odisha
India

Shrikanta Kumar Swain
Post graduate student Department of Medicine S.C.B Medical College, Cuttack ODISHA
India

Smaraka Ranjan Panda
DM Student Department of Nephrology S.C.B Medical College, Cuttack Odisha
India


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