• Ata Sedik Elsayed Dar Al Uloom University- Saudi Arabia
  • Azab Elsayed Azab


In chronic kidney failure, there is impairment in the excretion of toxic non-volatile solutes, with consequent increase in the plasma concentrations of all metabolites derived mainly from protein metabolism, characterized by increased urea and creatinine, the prevalence and severity of anemia are related to the kidney disease stage and the relative deficiency or reduction in erythropoietin production is the main cause. This study aimed at checking the correlation between anemia and chronic kidney diseases in patients who underwent hemodialysis in Sabratha Hospital in the West of Libya. This study was conducted on 60 patients (36 males and 24 females) with chronic renal failure from October 2015 to April 2016 and a group of 40 (20 males and 20 females) individuals as control. The results of the study concluded that there is a correlation between progression of chronic kidney diseases and reduction in hemoglobin, red blood cells count, hematocrit, and serum iron.

Keywords: Chronic kidney diseases, Chronic kidney disease, Anemia, Renal failure

Author Biography

Ata Sedik Elsayed, Dar Al Uloom University- Saudi Arabia
Assistant Professor


1. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis 2002;39 2 Suppl 1:S1-266.
2. Zhang QL, Rothenbacher D. Prevalence of chronic kidney disease in population-based studies: Systematic review. BMC Public Health
3. Foley RN, Murray AM, Li S, Herzog CA, McBean AM, Eggers PW, et al. Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population,
1998 to 1999. J Am Soc Nephrol 2005;16(2):489-95.
4. McCullough PA, Lepor NE. The deadly triangle of anemia, renal insufficiency, and cardiovascular disease: Implications for prognosis and treatment. Rev Cardiovasc Med 2005;6(1):1-10.
5. Macdougall IC, Eckardt KU, Locatelli F. Latest US KDOQI Anaemia Guidelines update – What are the implications for Europe? Nephrol Dial Transplant 2007;22:2738-42.
6. New JP, Aung T, Baker PG, Yongsheng G, Pylypczuk R, Houghton J, et al. The high prevalence of unrecognized anaemia in patients with diabetes and chronic kidney disease: A population-based study. Diabet Med 2008;25(5):564-9.
7. Mohanram A, Zhang Z, Shahinfar S, Keane WF, Brenner BM, Toto RD.
Anemia and end-stage renal disease in patients with type 2 diabetes and nephropathy. Kidney Int 2004;66(3):1131-8.
8. Astor BC, Muntner P, Levin A, Eustace JA, Coresh J. Association of kidney function with anemia: The Third National Health and Nutrition Examination Survey (1988-1994). Arch Intern Med
9. Thomas MC. Anemia in diabetes: Marker or mediator of microvascular disease? Nat Clin Pract Nephrol 2007;3(1):20-30.
10. Abensur H, Bastos MG, Canziani ME. Aspectos atuais da anemia na doença renal crônica. J Bras Nefrol 2006;28:104-7.
11. Abensur H. Anemia da doença renal crônica. J Bras Nefrol 2004;26:26-8.
12. Ajzen H, Schor N. Guia de Medicinaambulatorial e Hospitalar de
Nefrologia. 2a ed. São Paulo: Manole; 2005.
13. Pereira AB, Santos BF. Avaliação da função renal. In: Ajzen H, Schor N, editors. Guia de Medicinaambulatorial e Hospitalar de Nefrologia. 2a ed. São Paulo: Manole; 2005. p. 19-37.
14. Sodré FL, Costa JC, Lima JC. Avaliação da função e da lesão renal: Um desafio laboratorial. J Bras Patol Med Lab 2007;43:329-37.
15. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 2004;351(13):1296-305.
16. Canadian Organ Replacement Register Annual Data Report. (2007). Available from:
page=services_corr_e> (Version current at May 22, 2008.
17. Go AS, Yang J, Ackerson LM, Lepper K, Robbins S, Massie BM, et al. Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: The anemia in chronic heart failure: Outcomes and resource utilization (ANCHOR) study. Circulation 2006;113(23):2713-23.
18. Wali RK, Henrich WL. Chronic kidney disease: A risk factor for cardiovascular disease. Cardiol Clin 2005;23(3):343-62.
19. Al-Ahmad A, Rand WM, Manjunath G, Konstam MA, Salem DN, Levey AS, et al. Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 2001;38(4):955-62.
20. Rahman M, Brown CD, Coresh J, Davis BR, Eckfeldt JH, Kopyt N, et al. The prevalence of reduced glomerular filtration rate in older hypertensive patients and its association with cardiovascular disease: A report from the antihypertensive and lipid-lowering treatment to prevent heart attack trial. Arch Intern Med 2004;164(9):969-76.
21. Astor BC, Coresh J, Heiss G, Pettitt D, Sarnak MJ. Kidney function and anemia as risk factors for coronary heart disease and mortality: The Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J
22. Smith RE Jr. The clinical and economic burden of anemia. Am J Manag Care 2010;16 Suppl Issues: S59-66.
23. Mehdi U, Toto RD. Anemia, diabetes, and chronic kidney disease.
Diabetes Care 2009;32(7):1320-6.
24. van Nooten FE, Green J, Brown R, Finkelstein FO, Wish J. Burden of illness for patients with non-dialysis chronic kidney disease and anemia in the United States: Review of the literature. J Med Econ
25. Bastos MG, Bregman R, Kirsztajn GM. Chronic kidney diseases: Common and harmful, but also preventable and treatable. Rev Assoc Med Bras 2010;56(2):248-53.
26. Valderrábano F, Jofre R, López-Gómez JM. Quality of life in end-stage renal disease patients. Am J Kidney Dis 2001;38(3):443-64.
27. Abensur H. Deficiência de ferronadoença renal crônica. Rev Bras Hematol Hemoter 2010;32:95-8.
28. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16(1):31-41.
29. Erslev A. Humoral regulation of red cell production. Blood 1953;8(4):349-57.
30. Jacobson LO, Goldwasser E, Fried W, Plzak L. Role of the kidney in erythropoiesis. Nature 1957;179(4560):633-4.
31. Besarab A, Ayyoub F. Anemia in renal disease. In: Schrier RW, editor. Diseases of the Kidney and Urinary Tract. 8th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2007. p. 2406-30.
32. Vos FE, Schollum JB, Coulter CV, Doyle TC, Duffull SB, Walker RJ.
Red blood cell survival in long-term dialysis patients. Am J Kidney Dis
33. Poudel B, Yadav BK, Jha B, Raut KB, Pandeya DR. Prevalence and association of anemia with CKD: A hospistal based crosssectional study from Nepal. Biomed Res 2013;24(1):99-103.
34. Bueno CS, Frizzo MN. Anemia in chronic kidney disease in a Hospital in the Northwest region to the State of Rio Grande do Sul. J Bras Nefrol 2014;36(3):304-14.
35. de Francisco AL, Stenvinkel P, Vaulont S. Inflammation and its impact on anaemia in chronic kidney disease: From haemoglobin variability to hyporesponsiveness. NDT Plus 2009;2 Suppl 1:i18-26.
36. Fishbane S, Pollack S, Feldman HI, Joffe MM. Iron indices in chronic kidney disease in the National Health and Nutritional Examination Survey 1988-2004. Clin J Am Soc Nephrol 2009;4(1):57-61.
37. Mezzano S, Droguett A, Burgos ME, Ardiles LG, Flores CA, Aros CA, et al. Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy. Kidney Int Suppl 2003;(86):S64-70.
38. Thomas MC, MacIsaac RJ, Tsalamandris C, Jerums G. Elevated iron indices in patients with diabetes. Diabet Med 2004;21(7):798-802.
39. Babitt JL, Lin HY. Molecular mechanisms of hepcidin regulation: Implications for the anemia of CKD. Am J Kidney Dis 2010;55(4):726-41.
40. Hassoon WA, Melconian AK, Al-Safar JM. Study the relationship between hemodialysis patients and their ABO blood grouping as well as screening of hemodialysis access-related bacterial infections. Curr Res J Biol Sci 2013;5(6):291-5.
41. Rasmi Y, Makhdoomi K, Farshid S, Kheradmand F. Seroprevalence of anti-Helicobacter pylori and anticytotoxin-associated gene A antibodies according to ABO blood groups and rhesus status among hemodialysis patients. Iran J Kidney Dis 2011;5(3):214-20.
42. Dorgalaleh A, Mahmudi M, Tabibian S, Khatib ZK, Tamaddon GH, Moghaddam ES, et al. Anemia and thrombocytopenia in acute and chronic renal failure. Int J Hematol Oncol Stem Cell Res 2013;7(4):34-9.
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How to Cite
Elsayed, A. S., and A. E. Azab. “CORRELATION BETWEEN CHRONIC KIDNEY DISEASES AND HEMATOLGICAL DATA IN SABRATHA HOSPITAL IN LIBYA”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 2, Feb. 2017, pp. 291-6, doi:10.22159/ajpcr.2017.v10i2.15595.
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