• Takkella Nagamma MANIPAL UNIVERSITY
  • Akshay T Jagadeesh
  • Anjaneyulu K
  • Kumar Mr Bhat


Phytoestrogens are structurally similar to its mammalian counterparts and are capable of producing estrogen-like effects and non-steroidal in nature. Their affinity to bind to the estrogen receptors, a class of cytoplasmic proteins, is far less in comparison to the natural estrogen hormones found in humans and other animals or even the synthetically prepared estrogen and, therefore, are far less potent. Even so, the usage of phytoestrogen in either dietary or supplemental form in postmenopausal women is gaining interest, as opposed to the conventional estrogen replacement therapy (ERT), which was so far being used to alleviate the postmenopausal symptoms and believed, with little experimental/clinical evidence, to cause a significant reduction in the threat of coronary heart diseases (CHD). This usage of phytoestrogen follows from the fact that the overall health risks exerted by ERT outweigh the benefits, and to a little extent, the perception that synthetically prepared, so-called “prescription estrogen†interferes with what is otherwise a natural process. It is crucial to explore the alternatives that mimic the beneficial effects of ERT, especially with regard to the minimization of the risk of developing CHD and further evaluation of the aforementioned risks in terms of lipid profiling while simultaneously keeping the health risks to a minimum. This review discusses the scope of use of phytoestrogen specifically pertaining to lipid profiling, their possible health benefits, and adverse effects if any.

 Keywords: Phytoestrogens, Postmenopause, Lipid profile, Isoflavones.

Author Biography


Selection Grade lecturer

Department of Biochemsitry


1. Woodard GA, Brooks MM, Barinas-Mitchell E, Mackey RH, Matthews KA, Sutton-Tyrrell K. Lipids, menopause, and early atherosclerosis in Study of Women’s Health Across the Nation Heart women. Menopause 2011;18(4):376-84.
2. Jensen J, Nilas L, Christiansen C. Influence of menopause on serum lipids and lipoproteins. Maturitas 1990;12(4):321-31.
3. Yazdani S, Sharbatdaran M, Abedi Samakoosh M, Bouzari Z, Masoudi Z. Glucose tolerance and lipid profile changes after surgical
menopause. Caspian J Intern Med 2014;5(2):114-7.
4. Tuna V, Alkis I, Safiye AS, Imamoglu N, Bayram N, Ali Ismet T. Variations in blood lipid profile, thrombotic system, arterial elasticity
and psychosexual parameters in the cases of surgical and natural menopause. Aust N Z J Obstet Gynaecol 2010;50(2):194-9.
5. Bingham SA, Atkinson C, Liggins J, Bluck L, Coward A. Phytooestrogens: Where are we now? Br J Nutr 1998;79:393-406.
6. Dewell A, Hollenbeck CB, Bruce B. The effects of soy-derived
phytoestrogens on serum lipids and lipoproteins in moderately hypercholesterolemic postmenopausal women. J Clin Endocrinol
Metab 2002;87:118-21.
7. Grodstein F, Stampfer MJ, Manson JE, Colditz GA, Willett WC, Rosner B, et al. Postmenopausal estrogen and progestin use and the
risk of cardiovascular disease. N Engl J Med 1996;335(7):453-61.
8. Barrett-Connor E, Bush TL. Estrogen and coronary heart disease in women. JAMA 1991;265(14):1861-7.
9. Stampfer MJ, Colditz GA. Estrogen replacement therapy and coronary heart disease: A quantitative assessment of the epidemiologic evidence.
Prev Med 1991;20(1):47-63.
10. Mosca L, Grundy SM, Judelson D, King K, Limacher M, Oparil S, et al. Guide to preventive cardiology for women. AHA/ACC scientific
statement consensus panel statement. Circulation 1999;99(18):2480-4.
11. Subbiah MT. Estrogen replacement therapy and cardioprotection: Mechanisms and controversies. Braz J Med Biol Res 2002;35(3):271-6.
12. Mosca L, Collins P, Herrington DM, Mendelsohn ME, Pasternak RC, Robertson RM, et al. Hormone replacement therapy and cardiovascular
disease: A statement for healthcare professionals from the American Heart Association. Circulation 2001;104(4):499-503.
13. Beral V, Reeves G, Bull D, Green J; Million Women Study Collaborators. Breast cancer risk in relation to the interval between menopause and starting hormone therapy. J Natl Cancer Inst 2011;103(4):296-305.
14. Chlebowski RT, Anderson G, Manson JE, Pettinger M, Yasmeen S, Lane D, et al. Estrogen alone in postmenopausal women and breast
cancer detection by means of mammography and breast biopsy. J Clin Oncol 2010;28(16):2690-7.
15. Brinton LA, Felix AS. Menopausal hormone therapy and risk of endometrial cancer. J Steroid Biochem Mol Biol 2014;142:83-9.
16. Weiderpass E, Baron JA, Adami HO, Magnusson C, Lindgren A, Bergström R, et al. Low-potency oestrogen and risk of endometrial
cancer: A case-control study. Lancet 1999;353(9167):1824-8.
17. Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med
18. Hooper L, Kroon PA, Rimm EB, Cohn JS, Harvey I, Le Cornu KA, et al. Flavonoids, flavonoid-rich foods, and cardiovascular risk:
A meta-analysis of randomized controlled trials. Am J Clin Nutr 2008;88(1):38-50.
19. Rojas J, Londono C, Ciro Y. The health benefits of natural skin UVA photoprotective compounds found in botanical sources. Int J Pharm
Pharm Sci 2016;8(3):13-23.
20. Andres S, Abraham K, Appel KE, Lampen A. Risks and benefits of dietary isoflavones for cancer. Crit Rev Toxicol 2011;41(6):463-506.
21. Zhao L, Mao Z, Brinton RD. A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity
and neuroprotective activities in vitro and in vivo. Endocrinology 2009;150(2):770-83.
22. Murkies AL, Wilcox G, Davis SR. Clinical review 92: Phytoestrogens. J Clin Endocrinol Metab 1998;83:297-303.
23. Thame DM, Gardener CD, Haskell WL. Potential health benefits of dietary phytoestrogens: A review of clinical, epidemiological and
mechanistic evidence. J Clin Endocrinol Metab 1998;83(7):2223.
24. Thompson LU, Boucher BA, Liu Z, Cotterchio M, Kreiger N. Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan. Nutr Cancer 2006;54(2):184-201.
25. Gupta D, Kaur P. Phytochemical evaluation and in vitro antioxidant activity of few wonder seeds. Int J Pharm Pharm Sci 2016;8(7):98-104.
26. Schmitt E, Lehmann L, Metzler M, Stopper H. Hormonal and genotoxic activity of resveratrol. Toxicol Lett 2002;136(2):133-42.
27. Anthony MS, Clarkson TB, Hughes CL Jr, Morgan TM, Burke GL. Soybean isoflavones improve cardiovascular risk factors without
affecting the reproductive system of peripubertal rhesus monkeys. J Nutr 1996;126(1):43-50.
28. Cavallini DC, Bedani R, Bomdespacho LQ, Vendramini RC, Rossi EA. Effects of probiotic bacteria, isoflavones and simvastatin on lipid
profile and atherosclerosis in cholesterol-fed rabbits: A randomized double-blind study. Lipids Health Dis 2009;8:1.
29. Zhan S, Ho SC. Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am J Clin Nutr 2005;81(2):397-408.
30. Ferreira Ede S, Silva MA, Demonte A, Neves VA. Soy ß-conglycinin
(7S globulin) reduces plasma and liver cholesterol in rats fed hypercholesterolemic diet. J Med Food 2011;14(1-2):94-100.
31. Gudbrandsen OA, Wergedahl H, Mørk S, Liaset B, Espe M, Berge RK. Dietary soya protein concentrate enriched with isoflavones reduced
fatty liver, increased hepatic fatty acid oxidation and decreased the hepatic mRNA level of VLDL receptor in obese Zucker rats. Br J Nutr
32. Blum A, Lang N, Vigder F, Israeli P, Gumanovsky M, Lupovitz S, et al. Effects of soy protein on endothelium-dependent vasodilatation and
lipid profile in postmenopausal women with mild hypercholesterolemia. Clin Invest Med 2003;26:20-6.
33. Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S. Soy isoflavones lower serum total and LDL cholesterol in humans: A
meta-analysis of 11 randomized controlled trials. Am J Clin Nutr 2007;85:1148-56.
34. Sacks FM, Lichtenstein A, Van Horn L, Harris W, Kris-Etherton P, Winston M; American Heart Association Nutrition Committee. Soy
protein, isoflavones, and cardiovascular health: An American Heart Association Science Advisory for professionals from the Nutrition
Committee. Circulation 2006;113:1034-44.
35. Høie LH, Graubaum HJ, Harde A, Gruenwald J, Wernecke KD. Lipid-lowering effect of 2 dosages of a soy protein supplement in
hypercholesterolemia. Adv Ther 2005;22:175-86. 36. Anderson JW. Soyfoods effects on serum lipoproteins in humans:
Updated meta-analysis. Oral Presentation at 6 International Symposium on the Role of Soy in Preventing and Treating Chronic
Disease. Chicago; 2005.
37. Amani R. We-P14:413 effects of soy protein isoflavones on serum lipid profile and hormones of hypercholesterolemic men. 2006;7:438.
38. Reynolds K, Chin A, Lees KA, Nguyen A, Bujnowski D, He J. analysis of the effect of soy protein supplementation on serum lipids.
Am J Cardiol 2006;98:633-40.
39. Sedaghat A, Shahbazian H, Haidari F, Payami S, Jahanshahi The effect of soy nuts on glycemic control, lipid profile resistance in Type 2 diabetic patients. Endocr Metab Dis 2015;5:1-7.
40. Chandrareddy A, Muneyyirci-Delale O, McFarlane SI, Murad OM. Adverse effects of phytoestrogens on reproductive healththree cases. Complement Ther Clin Pract 2008;14(2):132-5.
41. Hodis HN, Mack WJ, Kono N, Azen SP, Shoupe D, Hwang-Levineet al. Isoflavone soy protein supplementation and atherosclerosis
progression in healthy postmenopausal women: Acontrolled trial. Stroke 2011;42(11):3168-75.
42. Campbell SC, Khalil DA, Payton ME, Arjmandi BH. One-year soy protein supplementation does not improve lipid postmenopausal women. Menopause 2010;17(3):587-93.
43. Wofford MR, Rebholz CM, Reynolds K, Chen J, Chen CS,Myers L, et al. Effect of soy and milk protein supplementation onserum lipid levels: A randomized controlled trial. Eur J Clin Nutr2012;66(4):419-25.
44. Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: A meta-analysis. Am J Clin Nutr 1999;69:30-42.
45. Prasad K, Mantha SV, Muir AD, Westcott ND. Reduction hypercholesterolemic atherosclerosis by CDC-flaxseed with very low
alpha-linolenic acid. Atherosclerosis 1998;136(2):367-75.
46. Shakir KA, Madhusudhan B. Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies. Indian J Clin Biochem 2007;22(1):117-21.
47. Prim CR, Baroncini LA, Précoma LB, Caron PH, Winter G, Poletti et al. Effects of linseed consumption for a short period of time profile and atherosclerotic lesions in rabbits fed a hypercholesterolaemic diet. Br J Nutr 2012;107(5):660-4.
48. Lucas EA, Wild RD, Hammond LJ, Khalil DA, Juma S, Daggy BPet al. Flaxseed improves lipid profile without altering bone metabolism in postmenopausal women. J Clin Endocrinol 2002;87(4):1527-32.
49. Pan A, Yu D, Demark-Wahnefried W, Franco OH, Lin X. Meta-analysis of the effects of flaxseed interventions on blood lipids. Am J Clin Nutr 2009;90:288-97.
50. Nogowski L. Effects of phytoestrogen-coumestrol carbohydrate metabolism in young ovariectomized independent of its estrogenicity. J Nutr Biochem 1999;10(1
51. Nogowski L, Nowak KW, Mackowiak P. Effect of phytooestrogen – coumestrol and oestrone on some aspects of carbohydrate in ovariectomized female rats. Arch Vet Pol 1992;32(3-4):79-84.
52. Béguin DP, Kincaid RL. 3-Hydroxy-3-methyl-glutaryl reductase activity in chicks fed coumestrol, a phytoestrogen. Poult Sci
53. Ahirwar D, Ahirwar B. Evaluation of antifertility activity foenum graecum seeds. Der Pharm Sin 2010;1(3):33-9.
54. Kumar P, Bhandari U, Jamadagni S. Fenugreek seed extract accumulation and ameliorates dyslipidemia in high fat obese rats. Biomed Res Int 2014;606021.
55. Abedinzade M, Nasri S, Omidi MJ, Porramezan B, Khanaki K. effect of fenugreek (Trigonella foenum-graecum) seed estradiol on serum apelin, glucose, lipids and insulin in ovariectomized rats. Biotechnol Health Sci 2015;2(3):e30402.
56. Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek blood glucose and serum lipids in type I diabetes. Eur J Clin 1990;44(4):301-6.
57. Vijayakumar MV, Pandey V, Mishra GC, Bhat MK. Hypolipidemic effect of fenugreek seeds is mediated through inhibition accumulation and upregulation of LDL receptor. Obesity (Silver Spring) 2010;18(4):667-74.
58. Chaturvedi U, Shrivastava A, Bhadauria S, Saxena JK, A mechanism-based pharmacological evaluation of Trigonella foenum graecum (fenugreek) seeds in regulation dyslipidemia and oxidative stress in hyperlipidemic rats. JPharmacol 2013;61(6):505-12.
59. Shamshad Begum S, Jayalakshmi HK, Vidyavathi HG, Gopakumar Abin I, Balu M, et al. A novel extract of fenugreek Husk (FenuSMARTâ„¢) alleviates postmenopausal symptoms and helps to establish the hormonal balance: A randomized, double-blind, controlled study. Phytother Res 2016;30:1775-84.
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How to Cite
Nagamma, T., A. T. Jagadeesh, A. K, and K. M. Bhat. “EFFECT OF PHYTOESTROGENS ON LIPID PROFILE: MINI REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 2, Feb. 2017, pp. 50-53, doi:10.22159/ajpcr.2017.v10i2.15684.
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