ANTIDIABETIC ACTIVITY OF CLERODENDRUM SERRATUM (L.) MOON LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Authors

  • MIHIR K KAR University Department of Pharmaceutical Sciences (UDPS), Utkal University, Vani Vihar, Bhubaneswar-751004
  • Trupti R Swain
  • Sagar K Mishra

Abstract

 Objective: The present study has been undertaken to evaluate the antidiabetic activity of Clerodendrum serratum leaves.

Methods: The fresh leaves were collected from Khandagiri hills of Khurda district in the state of Odisha, India and extracted successively with n-hexane, methanol, and water. The effect of extracts at the dose level of 400 mg/kg body weight was studied in normal, glucose-loaded, and streptozotocin (STZ)-induced diabetic rats along with glucose utilization potential in rat hemi-diaphragm.

Results: The test extracts showed a significant reduction of blood glucose level in normal, glucose-loaded, and STZ-induced diabetic rats and also exhibited better glucose utilization by isolated rat hemi-diaphragm. Methanol extract demonstrated maximum blood glucose lowering potential as compared to other extracts.

Conclusion: The leaf of C. serratum (L.) Moon is endowed with blood sugar lowering potential in both normal and diabetic rats.

Keywords: Clerodendrum serratum (L.) moon, Antidiabetic activity, Streptozotocin, Glucose-uptake

References

Akpan HB, Adefule AK, Fakoya FA. Caxton-Martins EA. Evaluation of LDH and G6-PDH activities in auditory relay centers of streptozotocin-induced diabetic wistar rats. J Anal Sci 2007;1:21-5.

Curtis J, Wilson C. Preventing type 2 diabetes mellitus. J Am Board Fam Pract 2005;18(1):37-43.

Subramoniam A, Pushpangadan P, Rajasekharan S, Evans DA, Latha PG, Valsaraj R. Effects of Artemisia pallens Wall. on blood glucose levels in normal and alloxan-induced diabetic rats. J Ethnopharmacol 1996;50(1):13-7.

Mukherjee PK, Saha K, Pal M, Saha BP. Effect of Nelumbo nucifera rhizome extract on blood sugar level in rats. J Ethnopharmacol 1997;58(3):207-13.

Berger W. Incidence of severe sideeffects during therapy with sulfonylureas and biguanides. Horm Metab Res Suppl 1985;15:111-5.

Pari L, Venkateswaran S. Effect of Coccinia indica on blood glucose, insulin and hepatic key enzymes in experimental diabetes. Pharm Biol 2002;40:165-70.

Singh MK, Khare G, Iyer SK, Sharwan G, Tripathi DK. Clerodendrum serratum: A clinical approach. J Appl Pharm Sci 2012;2:11-5.

Bhandary MJ, Chandrashekar KR, Kaveriappa KM. Medical ethnobotany of the Siddis of Uttara Kannada district, Karnataka, India. J Ethnopharmacol 1995;47(3):149-58.

Anderson EF. Ethnobotany of hill tribes of northern Thailand. II. Lahu medicinal plants. Econ Bot 1986;40(4):442-50.

Anderson EF. Ethnobotany of hill tribes of northern Thailand. I. Medicinal plants of Akha. Econ Bot 1986;40(1):38-53.

Narayanan N, Thirugnanasambantham P, Viswanathan S, Vijayasekaran V, Sukumar E. Antinociceptive, anti-inflammatory and antipyretic effects of ethanol extract of Clerodendron serratum roots in experimental animals. J Ethnopharmacol 1999;65(3):237-41.

Nyman U, Joshi P, Madsen LB, Pedersen TB, Pinstrup M, Rajasekharan S, et al. Ethnomedical information and in vitro screening for angiotensin-converting enzyme inhibition of plants utilized as traditional medicines in Gujarat, Rajasthan and Kerala (India). J Ethnopharmacol 1998;60(3):247-63.

Singh VK, Ali ZA. Folk medicines in primary health care: Common plants used for the treatment of fevers in India. Fitoterapia 1994;65(1):68-74.

Sachdev KS, Banerjee SK, Chakravarti RN. Preliminary chemical examination of the root-bark of Clerodendron serratum (linn) moon. Bull Calcutta Sch Trop Med 1965;13:17-8.

Mohamed AJ, Mohamed EA, Aisha AF, Ameer OZ, Ismail Z, Ismail N, et al. Antioxidant, antiangiogenic and vasorelaxant activities of methanolic extract of Clerodendrum serratum (Spreng.) leaves. J Med Plants Res 2012;6(3):348-60.

Vidya SM, Krishna V, Manjunatha BK, Mankani KL, Ahmed M, Singh SD. Evaluation of hepatoprotective activity of Clerodendrum serratum L. Indian J Exp Biol 2007;45(6):538-42.

Mackie TJ. Macroscopy. Mackie and McCartney. Practical Medical Microbiology. New York: Churchill Livingstone, Medical Division of Pearson Professional Limited; 1996. p. 152.

Bhujbal SS, Kumar D, Deoda RS, Kewatkar SM, Patil MJ. In-vitro and in-vivo Antiasthmatic studies of Clerodendrum serratum Linn in guinea pigs. Int J Pharm Res Dev 2010;2(4):1-6.

Khurnbongmayum AO, Khan ML, Tripathi RS. Ethnomedicinal plants in the sacred groves of Manipur. Indian J Tradit Knowl 2005;4(1):21 32.

Marles RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine 1995;2(2):137-89.

Adeneye AA, Adeleke TI, Adeneye AK. Hypoglycemic and hypolipidemic effects of the aqueous fresh leaves extract of Clerodendrum capitatum in Wistar rats. J Ethnopharmacol 2008;116(1):7-10.

Pandey R. Anti-diabetic activity of Clerodendrum (or Clerodendron) inerme using in vivo and in vitro studies, novel science. Int J Pharm Sci 2012;1:6.

Sneha JA, Chaudhari S, Alpha-amylase inhibitory and hypoglycemic activity of Clerodendrone multiflorum Linn. Stems. Asian J Pharm Clin Res 2011;4(2):99.

Satapathy KB, Chand PK. Herbal Cure of Diabetes. Germany: Lap Lambert AG & Co.; 2010. p. 217.

Harborne JB. Phytochemical Methods – A Guide to Modern Techniques of Plant Analysis. London: Chapmann and Hall; 1973. p. 49-188.

Jain S, Bhatia G, Barik R, Kumar P, Jain A, Dixit VK. Antidiabetic activity of Paspalum scrobiculatum Linn. in alloxan induced diabetic rats. J Ethnopharmacol 2010;127(2):325-8.

Arulselvan P, Subramanian SP. Beneficial effects of Murraya koenigii leaves on antioxidant defense system and ultra structural changes of pancreatic beta-cells in experimental diabetes in rats. Chem Biol Interact 2007;165(2):155-64.

Kar DM, Maharana L, Pattnaik S, Dash GK. Studies on hypoglycaemic activity of Solanum xanthocarpum Schrad. & Wendl. fruit extract in rats. J Ethnopharmacol 2006;108(2):251-6.

Sarulmozhia S, Mazumderb PM, Lohidasanc S, Thakurdesai P. Antidiabetic and antihyperlipidemic activity of leaves of Alstonia scholans Linn R. Br. Eur J Integr Med 2010;2:23-32.

Day C, Cartwright T, Provost J, Bailey CJ. Hypoglycaemic effect of Momordica charantia extracts. Planta Med 1990;56(5):426-9.

Published

2014-11-01

How to Cite

KAR, M. K. ., T. R. Swain, and S. K. Mishra. “ANTIDIABETIC ACTIVITY OF CLERODENDRUM SERRATUM (L.) MOON LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 7, no. 5, Nov. 2014, pp. 260-3, https://innovareacademics.in/journals/index.php/ajpcr/article/view/1572.

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