ANTIDIABETIC ACTIVITY OF CLERODENDRUM SERRATUM (L.) MOON LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Â Objective: The present study has been undertaken to evaluate the antidiabetic activity of Clerodendrum serratum leaves.
Methods: The fresh leaves were collected from Khandagiri hills of Khurda district in the state of Odisha, India and extracted successively with n-hexane, methanol, and water. The effect of extracts at the dose level of 400 mg/kg body weight was studied in normal, glucose-loaded, and streptozotocin (STZ)-induced diabetic rats along with glucose utilization potential in rat hemi-diaphragm.
Results: The test extracts showed a significant reduction of blood glucose level in normal, glucose-loaded, and STZ-induced diabetic rats and also exhibited better glucose utilization by isolated rat hemi-diaphragm. Methanol extract demonstrated maximum blood glucose lowering potential as compared to other extracts.
Conclusion: The leaf of C. serratum (L.) Moon is endowed with blood sugar lowering potential in both normal and diabetic rats.
Keywords: Clerodendrum serratum (L.) moon, Antidiabetic activity, Streptozotocin, Glucose-uptake
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