• MIHIR K KAR University Department of Pharmaceutical Sciences (UDPS), Utkal University, Vani Vihar, Bhubaneswar-751004
  • Trupti R Swain
  • Sagar K Mishra


 Objective: The present study has been undertaken to evaluate the antidiabetic activity of Clerodendrum serratum leaves.

Methods: The fresh leaves were collected from Khandagiri hills of Khurda district in the state of Odisha, India and extracted successively with n-hexane, methanol, and water. The effect of extracts at the dose level of 400 mg/kg body weight was studied in normal, glucose-loaded, and streptozotocin (STZ)-induced diabetic rats along with glucose utilization potential in rat hemi-diaphragm.

Results: The test extracts showed a significant reduction of blood glucose level in normal, glucose-loaded, and STZ-induced diabetic rats and also exhibited better glucose utilization by isolated rat hemi-diaphragm. Methanol extract demonstrated maximum blood glucose lowering potential as compared to other extracts.

Conclusion: The leaf of C. serratum (L.) Moon is endowed with blood sugar lowering potential in both normal and diabetic rats.

Keywords: Clerodendrum serratum (L.) moon, Antidiabetic activity, Streptozotocin, Glucose-uptake


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How to Cite

KAR, M. K. ., T. R. Swain, and S. K. Mishra. “ANTIDIABETIC ACTIVITY OF CLERODENDRUM SERRATUM (L.) MOON LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 7, no. 5, Nov. 2014, pp. 260-3,



Original Article(s)