IN VITRO ANTIOXIDANT ACTIVITY, IN VIVO ANTIPYRETIC AND ANTI-INFLAMMATORY ACTIVITIES OF PARONYCHIA CAPITATA L.


Soumia Bouzidi, Benkiki Naima, Allaoua Zina

Abstract


ABSTRACT
Objective: The aim of this study is to evaluate the in vitro antioxidant activity of Paronychia capitata various extracts, acute toxicity, the in vivo
antipyretic and anti-inflammatory activities of the n-butanol extract.
Methods: The antioxidant properties were tested using 2,2-diphenyl 1-picrylhydrazyl radical scavenging and β-carotene linoleic acid system, the
total phenolic and flavonoid contents were determined. Furthermore, anti-inflammatory activity and antipyretic activity of the n-butanol extract
were assessed on male Wistar rats at the dose levels 250, 500 mg/kg body weight, using the egg albumin-induced edema, and brewer’s yeast-induced
pyrexia method, respectively.
Results: The n-butanol extract of P. capitata had considerably the highest antiradical activity with inhibitory concentration 50 value of 8.667 μg/ml.
Conclusion: The experimental data demonstrated that n-butanol extract of P. capitata possess significantly remarkable anti-inflammatory and
antipyretic activities compared to the standard drugs.
Keywords: Caryophyllaceae, Flavonoid, Inflammation, Fever, Paronychia capitata.


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About this article

Title

IN VITRO ANTIOXIDANT ACTIVITY, IN VIVO ANTIPYRETIC AND ANTI-INFLAMMATORY ACTIVITIES OF PARONYCHIA CAPITATA L.

DOI

10.22159/ajpcr.2017.v10i3.15981

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 177-179

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

225 Views | 118 Downloads

Authors & Affiliations

Soumia Bouzidi
Laboratoire de Biotechnologie des Molécules Bioactives et de la Physiopathologie Cellulaire. Faculté des sciences de la nature et de la vie. Université de Batna-2,Batna, Algérie
Algeria

Benkiki Naima

Allaoua Zina


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