MESENCHYMAL STEM CELLS: AN INNOVATIVE APPROACH IN PHARMACOKINETICS


Seema Tripathy, Prafulla Kumar Mohanty

Abstract


ABSTRACT
Multipotent mesenchymal stem cells (MSCs) are special kind of stem cells which originate from mesenchyme. These cells can be used as an imperative
tool to study reproductive toxicity, carcinogenicity, mutagenicity, genotoxicity, and pharmacokinetics. This novel system may reveal toxicantinduced
etiology, decipher detailed understanding on molecular mechanisms of toxicants induced pathways and also enumerate the safe dose of
an investigational product. Hence, this could ultimately replace, improve or overtake current predictive models in toxicology. The particular review
describes the utilization of MSCs in different field of toxicological and pharmacological research.
Keywords: Mesenchymal stem cells, Toxicant, Etiology, Pharmacokinetics.


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References


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About this article

Title

MESENCHYMAL STEM CELLS: AN INNOVATIVE APPROACH IN PHARMACOKINETICS

DOI

10.22159/ajpcr.2017.v10i3.16023

Date

01-03-2017

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Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 25-36

Print ISSN

0974-2441

Online ISSN

2455-3891

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148 Views | 278 Downloads

Authors & Affiliations

Seema Tripathy

Prafulla Kumar Mohanty


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