PREPARATION AND CHARACTERIZATION OF SOLID DISPERSION FAMOTIDINE – MANNITOL BY CO-GRINDING METHOD


Lili Fitriani, Sherly Ramadhani, Erizal Zaini

Abstract


ABSTRACT
Objective: This study aims to prepare and characterize solid dispersion of famotidine using mannitol to enhance the solubility and dissolution rate.
Methods: Solid dispersions were prepared by co-grinding method in 9 formulas. The ratio of famotidine and mannitol was varied (1:1, 1:2, 2:1 w/w),
and each ratio was milled at three different times (30, 60, and 90 minutes). The physical mixture was also prepared as comparison at ratio 1:1 w/w.
Solid dispersions were characterized by X-ray diffraction analysis, Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry
(DSC) analysis, scanning electron microscopy (SEM), particle size analysis, solubility, and dissolution rate study. The assay of famotidine was done
using a UV spectrophotometer.
Results: The highest solubility of famotidine in solid dispersion was obtained in F2 (ratio 1:2 and grinding time 30 minutes). The solubility of intact
famotidine, physical mixture, and solid dispersion F2 was 1.630±0.027, 2.757±0.096, and 3.272±0.076 mg/ml, respectively. X-ray diffractogram of
solid dispersion F2 showed a decrease in the peak intensity of famotidine. Thermogram of DSC showed a decrease of famotidine melting point for both
physical mixture and solid dispersion. Photomicrograph of SEM indicated the changes in morphology solid dispersion compared to intact substances.
FTIR analysis showed no chemical interaction between famotidine and mannitol. The particle size analysis showed a reduction in the particle size
of the solid dispersion. The dissolution result after 60 minutes was 85.029%, 86.166%, 92.057% for intact famotidine, physical mixture, and solid
dispersion F2, respectively.
Conclusion: Solid dispersion increased solubility and dissolution rate.
Keywords: Solid dispersion, Famotidine, Mannitol, Co-grinding, Solubility.


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About this article

Title

PREPARATION AND CHARACTERIZATION OF SOLID DISPERSION FAMOTIDINE – MANNITOL BY CO-GRINDING METHOD

DOI

10.22159/ajpcr.2017.v10i3.16112

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 249-253

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

205 Views | 240 Downloads

Authors & Affiliations

Lili Fitriani
Faculty of Pharmacy Andalas University
Indonesia

Sherly Ramadhani
Faculty of Pharmacy Andalas University
Indonesia

Erizal Zaini
Faculty of Pharmacy Andalas University
Indonesia


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