PREPARATION AND EVALUATION OF CHITOSAN SODIUM ALGINATE CARBAMAZEPINE MICROSPHERES


Sreeja C Nair, Karthika Ramesh, Krishnapriya M, Asha Paul

Abstract


ABSTRACT
Objective: The objective behind our study is that a mucoadhesive rectal hydrogel chitosan sodium alginate carbamazepine (CBZ) microspheres for
the purpose of controlled release for the treatment of epilepsy to avoid the possible side effects.
Methods: The study was conducted to formulate controlled release chitosan sodium alginate CBZ microspheres with the dispersion of CBZ into the
natural polymers chitosan and sodium alginate forming microspheres conducting along with their evaluation studies.
Results: The formulated microspheres were subjected to various evaluation parameters, and all the physical parameters examined are within the
acceptable limits. Further, the optimized microsphere formulation (CM5) was characterized. Hence, the developed optimized microsphere formulation
(CM5) seems to be a viable substitute to conventional drug delivery system for the effective management of epilepsy.
Conclusion: The prepared formulation also provides a desired CBZ loaded sodium alginate microspheres with the controlled release drug delivery.
Keywords: Carbamazepine, Sodium alginate microspheres, Particle size.


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About this article

Title

PREPARATION AND EVALUATION OF CHITOSAN SODIUM ALGINATE CARBAMAZEPINE MICROSPHERES

DOI

10.22159/ajpcr.2017.v10i3.16145

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 271-276

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

140 Views | 173 Downloads

Authors & Affiliations

Sreeja C Nair
LECTURER,DEPARTMENT OF PHARMACEUTICS, AMRITA SCHOOL OF PHARMACY,AMRITA VISHWAVIDYAPEETHAM UNIVERSITY, AIMS- PONEKKARA P.O, KOCHI, KERALA, INDIA.
India

Karthika Ramesh

Krishnapriya M

Asha Paul


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