IMPROVEMENT OF DISSOLUTION RATE OF VALSARTAN BY SOLID DISPERSION SYSTEM USING D(−) MANNITOL


Erizal Zaini, Salman Umar, Nurhidayah Nurhidayah

Abstract


ABSTRACT
Objective: To improve dissolution rate of valsartan from solid dispersion system of valsartan and D(−) mannitol using co-grinding approach.
Methods: Valsartan solid dispersion with different ratio of D(−) mannitol (1:1; 1:3 and 1: 5) were prepared by co-grinding method. Solid state
characterization of the solid dispersion system was evaluated in term of crystallographic properties (powder X-ray diffraction), thermal behavior
(differential scanning calorimetry [DSC]) and morphology (scanning electron microscope). The profile of dissolution rate was examined using USP
dissolution apparatus type I at a temperature of 37±0.5°C.
Results: Based on thermal analysis DSC and powder X-ray diffraction analysis, valsartan was transformed from semicrystalline phase to amorphous
state as indicated by the disappearance of its melting endothermic peaks and the characteristic diffraction peaks. The in vitro dissolution rate study
revealed that all solid dispersion system showed significant increase in dissolution rate compared with the intact valsartan.
Conclusion: Solid dispersion of valsartan with D(−) mannitol prepared by co-grinding technique has successfully improved the dissolution rate
compared with intact valsartan.
Keywords: Valsartan, D(−) mannitol, Solid dispersion, Co-grinding, Dissolution rate.


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References


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About this article

Title

IMPROVEMENT OF DISSOLUTION RATE OF VALSARTAN BY SOLID DISPERSION SYSTEM USING D(−) MANNITOL

DOI

10.22159/ajpcr.2017.v10i3.16171

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 288-290

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

155 Views | 244 Downloads

Authors & Affiliations

Erizal Zaini
Faculty of Pharmacy Andalas University
Indonesia

Salman Umar
Faculty of Pharmacy Andalas UNiversity
Indonesia

Nurhidayah Nurhidayah
Faculty of Pharmacy Andalas University
Indonesia


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