EVALUATION OF ANTIMICROBIAL ACTIVITY OF GREEN-SYNTHESIZED MANGANESE OXIDE NANOPARTICLES AND COMPARATIVE STUDIES WITH CURCUMINANILINE FUNCTIONALIZED NANOFORM


Muhamed Haneefa M, Jayandran M, Balasubramanian V

Abstract


ABSTRACT
Objective: Metal oxide nanoparticles are widely attracted researchers due to their potential applications in a variety of fields, especially medicinal
importance. It has been shown that biofunctionalization of metal nanoparticles with the specified bioactive materials produces the significantly
improved bioactive materials with the essential biological properties and advanced features. According to the reports, manganese oxide nanoparticles
(MONPs) possess highly magnetic properties leads to develop for use in research and biomedical applications. In this evaluation, we focused on the
synthesis of MONPs through a green methodology and their antimicrobial activity changes when functionalized with curcuminaniline derived from
turmeric plants.
Methods: First, curcumin has been isolated from turmeric plant (BSR-01) to synthesize curcuminaniline biomaterial. On the other hand, manganese
nanoparticles are synthesized by the green synthesis method using lemon extract and curcumin. Finally, the synthesized curcuminaniline is
functionalized with MONPs. The synthesized nanoparticles are characterized by ultraviolet-visible, Fourier transform infrared, scanning electron
microscope and transmission electron microscopy techniques. The antimicrobial activity of the obtained nonfunctionalized and biofunctionalized
nanoforms are tested against some Gram-negative and Gram-positive bacterial strains as well as fungal strains.
Results: The morphological studies represented that MONPs are of eclipsed and spherical morphology with size about 50±5 nm and biofunctionalized
nanoparticles are of spherical morphology with size about 50±10 nm. The antibacterial and antifungal tests revealed that biofunctionalized MONPs
are exhibited significantly higher antimicrobial activity.
Conclusion: This investigation clearly demonstrated that MONPs are shown significantly higher biocidal activity when biofunctionalized with
modified curcumin material. This may help in the future medicinal and pharmaceutical industries to develop new inventions.
Keywords: Green synthesis, Nanoparticles, Curcumin, Curcuminaniline, Soxhlet extraction, Antimicrobial activity.


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About this article

Title

EVALUATION OF ANTIMICROBIAL ACTIVITY OF GREEN-SYNTHESIZED MANGANESE OXIDE NANOPARTICLES AND COMPARATIVE STUDIES WITH CURCUMINANILINE FUNCTIONALIZED NANOFORM

DOI

10.22159/ajpcr.2017.v10i3.16246

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 347-352

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

154 Views | 175 Downloads

Authors & Affiliations

Muhamed Haneefa M
AMET University, Chennai, India
India

Jayandran M
PG & Research Dept of chemistry, Thiruvalluvar Govt arts college, Namakkal, India
India

Balasubramanian V
AMET University, Chennai, India
India


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