EVALUATION OF NEPHROPROTECTIVE ACTIVITY OF MENTHA ARVENSIS IN CISPLATIN INDUCED NEPHROTOXICITY
Present study was performed to evaluate the effect of Mentha arvensis on cisplatin-induced nephrotoxicity in Sprague-Dawley rats. The M. arvensis
hydroalcoholic extract (MAHE) was administered orally at two dose levels (200 mg/kg and 400 mg/kg). The kidney function test (estimation of serum
creatinine, total protein, blood urea nitrogen [BUN], and urea), oxidative stress study (estimation of superoxide dismutase [SOD] activity, glutathione
content, and lipid peroxides [LPO]), and histological studies were also conducted. MAHE was found effective at both doses, although high dose
(400 mg/kg) was found more effective, which was evidenced by decrease in serum creatinine, total protein, BUN, urea, and LPO and increased in SOD
activity. Histopathological studies were also confirmed the nephroprotective action of MAHE. Present investigation revealed that M. arvensis showed
nephroprotective effect on cisplatin nephrotoxicity in Sprague-Dawley rats which may be due to the presence of flavonoids and related compounds.
Keywords: Mentha arvensis, Pudina, Nephroprotective activity, Nephrotoxicity.
Singh NP, Ganguli A, Prakash A. Drug-induced kidney diseases.
J Assoc Physicians India 2003;51:970-9.
Mohana LS, Usha KR, Sandhya RK. A review on medicinal plants for
nephroprotective activity. Asian J Pharm Clin Res 2012;5(4):8-14.
Verma SM, Arora H, Dubey R. Anti - inflammatory and
sedative - hypnotic activity of the methanolic extract of the leaves of
Mentha arvensis. Anc Sci Life 2003;23(2):95-9.
Lund RG, Serpa R, Nascente PD, Ribeiro GA, Freitag RA, Pino FA.
In-vitro study on the antimicrobial effect of hydroalcoholic extracts
from Mentha arvensis L. (Lamiaceae) against oral pathogens. Acta Sci
Biol Sci 2012;34(4):437-42.
Jyothi B, Jagadeesh S, Naidu KA, Kumr SB, Keerthi BL, Laskshmi
SM. Protective effect of methanolic extract of Mentha arvensis l. leaves
on haloperidol induced extrapyramidal movement disorders in albino
rats. Pharmanest. Int J Adv Pharm Sci 2011;2(2-3):179-88.
Londonkar RL, Poddar PV. Studies on activity of various extracts of
Mentha arvensis Linn against drug induced gastric ulcer in mammals.
World J Gastrointest Oncol 2009;1(1):82-8.
Patil K, Mall A. Hepatoprotective activity of Mentha arvensis Linn.
leaves against CCl4
induced liver damage in rats. Asian Pac J Trop Dis
Talele BD, Mahajan RT, Chopda MZ. Nemade NV. Nephroprotective
plants: A review. Int J Pharm Pharm Sci 2012;4(1):8-16.
Paoletti F, Aldinucci D, Mocali A, Caparrini A. A sensitive
spectrophotometric method for the determination of superoxide
dismutase activity in tissue extracts. Anal Biochem 1986;154:536-41.
Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys
Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues
by thiobarbituric acid reaction. Anal Biochem 1979;95(2):351-8.
Hanigan MH, Devarajan P. Cisplatin nephrotoxicity: Molecular
mechanisms. Cancer Ther 2003;1:47-61.
Chaudhary H, Santhosh B, Rao NR. Experimental appraisal of nephroprotective
activity of Varunadi loha. Int Ayur Med J 2013;1(4):1-8.
Zaveri M, Desai N, Movaliya V. Effect of Ocimum basilicum on cisplatin
models of acute renal failure. Adv Res Pharm Biol 2011;1(2):91-100.
Kidney Function Test. Available from: http://www.wikipaedia.com/.
[Last accessed on 2014 Apr 10].
Sakr AS, Al-Amoudi WM. Effect of leave extract of Ocimum basilicum
on deltamethrin induced nephrotoxicity and oxidative stress in albino
rats. J Appl Pharm Sci 2012;2(5);22-7.
Sapakal VD, Shikalgar TS, Ghadge RV, Adnaik RS, Naikwade NS. Invivo
screening of antioxidant profile: A review. J Herb Med Toxicol
Aslam M, Dayal R, Javed K, Parray SA, Jetley S, Samim M.
Nephroprotective effects of methanolic extract of Peucedanum grande
against acute renal failure induced by potassium dichromate in rat. Int J
Pharm Sci Drug Res 2013;5(2):45-9.
Cheng-zhe J, Ilhyun H, Seyoung C. Decursin mediated protection on
cisplatin-induced nephrotoxicity in SD rats and BDF1 mice. J Northeast
Agric Univ 2012;19(1):50-6.
Available from: http://www.metametrix.com/test-menu/profiles/
oxidative-stress indicators/lipid-peroxides. [Last accessed 2014 Apr 10].
Ravindra P, Bhiwgade DA, Kulkarni S, Rataboli PV, Dhume CY.
Cisplatin induced histological changes in renal tissue of rat. J Cell Anim
Suresh SN, Rathishkumar S, Rajeswari V, Sagadevan P, Gayathri S,
Vithya ED. Studies on phytochemical composition and antibacterial
potential of methanolic extract of Mentha arvensis. Linn. Int J Pharm
Res Dev 2012;4(8):1-4.
Sugandhi B, Rachel M, Bai GM. Antimicrobial activity of Mentha
arvensis l. lamiaceae. J Adv Laboratory Res Biol 2011;2(I):8-11.
Gopalakrishnan D, Sekar G, Manivannan B, Ravi A, Sathiavelu M,
Arunachalam S. Quantitative analysis of total phenolic content and
antioxidant activity of Mentha arvensis L. and Coriandrum sativum L.
Int J Universal Pharm Life Sci 2013;13(3):1-4.
How to Cite
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.