HYPOLIPIDEMIC POTENTIAL OF METHANOLIC EXTRACT OF GRACILARIA CORTICATA ON STREPTOZOTOCIN-INDUCED DIABETIC RATS


Sekar Subashini, Kavasseri Ganesan Kripa, Kodukur Viswanathan Pugalendi

Abstract


ABSTRACT
Objectives: Diabetes mellitus is associated with profound alterations in the levels of plasma lipids and the lipoprotein profile. Herbs and herbal drug
preparations find wide use in alleviating the complications of uncontrolled diabetes owing to their low cost and lesser side effects. This study was
aimed at establishing the hypolipidemic effect of methanolic extract of sea weed Gracilaria corticata on streptozotocin (STZ)-induced diabetic rats.
Methods: STZ-induced Wistar male albino rats were administered with methanolic extract of Gracilaria corticata (MGC) at a dosage of 100 mg/kg
BW/day per orally for 45 days. Glibenclamide (600 μg/kg BW/day) administered rats served as standard drug control. Animals were sacrificed on
46th day, biochemical parameters associated with lipid metabolism were analyzed in blood and tissue samples, statistical significance determined.
Results: Elevated levels of total cholesterol, triglycerides, and free fatty acids were observed in the plasma and tissues of diabetic rats as compared to
MGC and glibenclamide treated groups. The diabetic rats also had elevated levels of low-density lipoprotein (LDL-C) and very low-density lipoprotein
(VLDL-C) and decreased levels of high-density lipoprotein (HDL-C) while the MGC and glibenclamide treated rats showed near normal levels of these
indices.
Conclusion: This study establishes the hypolipidemic potential of MGC in STZ-induced diabetic rats.
Keywords: Gracilaria corticata, Diabetes mellitus, Hypolipidemic, Streptozotocin.


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About this article

Title

HYPOLIPIDEMIC POTENTIAL OF METHANOLIC EXTRACT OF GRACILARIA CORTICATA ON STREPTOZOTOCIN-INDUCED DIABETIC RATS

DOI

10.22159/ajpcr.2017.v10i3.16373

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 402-405

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

128 Views | 119 Downloads

Authors & Affiliations

Sekar Subashini
Research Scholar, Department of Biotechnology, School of Life Sciences, Vels University, Pallavaram, Chennai-600117

Kavasseri Ganesan Kripa
DEPARTMENT OF BIOCHEMISTRY, SCHOOL OF LIFE SCIENCES, VELS UNIVERSITY
India

Kodukur Viswanathan Pugalendi


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