A RANDOMIZED, OPEN LABEL, COMPARATIVE STUDY OF LYSINE CREAM WITH STANDARD TREATMENT IN PATIENTS WITH SECOND DEGREE SUPERFICIAL BURNS


Saravanan Periyannan, Chenthamarai G

Abstract


Objective: To evaluate the efficacy and tolerability of lysine cream in patients with second-degree superficial burns.

Methods: In this randomized, open label, comparative study patients with second degree superficial burns received either combination of lysine cream 15% and silver sulfadiazine cream 1% or sulfadiazine cream 1% alone, twice daily for period of 4 weeks. The primary outcome, pain, discharge, size and total body surface area (TBSA) were assessed in each visits.

Results: Patients in the study group showed significant change than the control group in pain, discharge, size, and TBSA during the first 4 weeks after treatment. In addition, significantly more patients in lysine group had adequate relief of itching and increased epithelialization.

Conclusions: Combination of lysine cream and silver sulfadiazine cream for 4 weeks provided significant relief of pain, discharge, size, TBSA, and itching. Lysine cream was well tolerated.

 


Keywords


Growth factor, Angiogenesis, Lysine, Body surface area.

| PDF |

References


Forjuoh SN. Burns in low- and middle-income countries: a review of available literature on descriptive epidemiology, risk factors, treatment, and prevention. Burns 2006; 32:529.

Daurea Abadia De-Souza and Lewis Joel Greene. Pharmacological Nutrition after Burn Injury. The journal of Nutrition Vol. 128 No. 5 May 1998, pp.797-803

Debatosh Datta, Akshay Bhinge & Vidya Chandran (2001) Lysine: Is it worth more? Cytotechnology 36: 3-32

Datta D.Essential amino acid lysine and its analogues support faster and qualitatively better healing of wounds (2000). www.pharmatransfer.com

Mozingo, W. D. (2001) Thermal Injury. In: Corson, D. J. and Williamson, C. N. R. (eds.) Surgery. Mosby: New York. Section 2, ch13, pp.1-12.

R.K. Gupta, A. Agarwal, S. Agarwal, Reversal Of Acute Human Brain Ischemic Injury By Lysine Induced Therapeutic Angiogenesis: Preliminary Results Of A Pilot Study. The Internet Journal of Neurology. 2005 Volume 4 Number 1

Alain Siméon, Yanusz Wegrowski, Yannick Bontemps Expression of Glycosaminoglycans and Small Proteoglycans in Wounds: Modulation by the Tripeptide – Copper Complex Glycyl-L-Histidyl-L-Lysine-Cu2+, Faculté de Médecine, Reims, France. Journal of Investigative Dermatology (2000) 115, 962–968; doi:10.1046/j.1523-1747. 2000. 00166.




About this article

Title

A RANDOMIZED, OPEN LABEL, COMPARATIVE STUDY OF LYSINE CREAM WITH STANDARD TREATMENT IN PATIENTS WITH SECOND DEGREE SUPERFICIAL BURNS

Keywords

Growth factor, Angiogenesis, Lysine, Body surface area.

DOI

10.22159/ajpcr.2017.v10i5.16431

Date

01-05-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 5 May 2017 Page: 219-221

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

211 Views | 237 Downloads

Authors & Affiliations

Saravanan Periyannan
Department of Pharmacology, Coimbatore Medical College, Coimbatore, Tamil Nadu, India.
India

Chenthamarai G
Department of Pharmacology, Madras Medical College, Chennai, Tamil Nadu, India
India


Article Tools


Email this article (Login required)
Email the author (Login required)

Refbacks

  • There are currently no refbacks.