A RANDOMIZED, OPEN LABEL, COMPARATIVE STUDY OF LYSINE CREAM WITH STANDARD TREATMENT IN PATIENTS WITH SECOND DEGREE SUPERFICIAL BURNS

  • Saravanan Periyannan Department of Pharmacology, Coimbatore Medical College, Coimbatore, Tamil Nadu, India.
  • Chenthamarai G Department of Pharmacology, Madras Medical College, Chennai, Tamil Nadu, India

Abstract

Objective: To evaluate the efficacy and tolerability of lysine cream in patients with second-degree superficial burns.

Methods: In this randomized, open label, comparative study patients with second degree superficial burns received either combination of lysine cream 15% and silver sulfadiazine cream 1% or sulfadiazine cream 1% alone, twice daily for period of 4 weeks. The primary outcome, pain, discharge, size and total body surface area (TBSA) were assessed in each visits.

Results: Patients in the study group showed significant change than the control group in pain, discharge, size, and TBSA during the first 4 weeks after treatment. In addition, significantly more patients in lysine group had adequate relief of itching and increased epithelialization.

Conclusions: Combination of lysine cream and silver sulfadiazine cream for 4 weeks provided significant relief of pain, discharge, size, TBSA, and itching. Lysine cream was well tolerated.

 

Keywords: Growth factor, Angiogenesis, Lysine, Body surface area.

Author Biography

Saravanan Periyannan, Department of Pharmacology, Coimbatore Medical College, Coimbatore, Tamil Nadu, India.
Dr.P.saravanan M.D., Assistant professor in Pharmacology, Coimbatore Medical College, Coimbatore, Tamilnadu.

References

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How to Cite
Periyannan, S., and C. G. “A RANDOMIZED, OPEN LABEL, COMPARATIVE STUDY OF LYSINE CREAM WITH STANDARD TREATMENT IN PATIENTS WITH SECOND DEGREE SUPERFICIAL BURNS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 5, May 2017, pp. 219-21, doi:10.22159/ajpcr.2017.v10i5.16431.
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Original Article(s)